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How to get fromBuffalo to Missouriby plane, train (Amtrak), bus (Greyhound), car, or bus

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There are 9 ways to get from Buffalo to Missouri by plane, train (Amtrak), bus (Greyhound), car, or bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Buffalo Niagara International Airport to Lambert–St. Louis International Airport

    best
    1. Fly from Buffalo Niagara International Airport (BUF) to Lambert–St. Louis International Airport (STL)plane plane BUF - STL
    6h 14m
    $105–605

  2. Train (Amtrak)

    1. Take the train from Buffalo Depew Station to Chicago Union Stationtrain train Lake Shore Limited
    2. Take the train from Chicago Union Station to Kansas Citytrain train Southwest Chief / ...
    20h 25m
    $242–692

  3. Bus

    1. Take the bus from Buffalo to Akronbus bus
    2. Take the bus from Akron to Cambridgebus bus
    3. Take the bus from Cambridge, OH to St Louis Bus Stationbus bus
    4. Take the bus from St Louis Bus Station to Kansas City Bus Stationbus bus
    23h 5m
    $140–301

  4. Drive  977.1 mi

    1. Drive from Buffalo to Kansas Citycar car 977.1 mi
    16h 36m
    $179–258

  5. Fly Buffalo Niagara International Airport to Columbia Regional Airport

    1. Fly from Buffalo Niagara International Airport (BUF) to Columbia Regional Airport (COU)plane plane BUF - COU
    6h 17m
    $137–517

  6. Fly Buffalo Niagara International Airport to Springfield-Branson National Airport

    1. Fly from Buffalo Niagara International Airport (BUF) to Springfield-Branson National Airport (SGF)plane plane BUF - SGF
    6h 25m
    $113–502

  7. Fly Buffalo Niagara International Airport to Kansas City

    1. Fly from Buffalo Niagara International Airport (BUF) to Kansas City (MCI)plane plane BUF - MCI
    7h 11m
    $132–702

  8. Bus to Toronto Pearson International Airport, fly to Lambert–St. Louis International Airport

    1. Take the bus from Buffalo to Mississaugabus bus
    2. Fly from Toronto Pearson International Airport (YYZ) to Lambert–St. Louis International Airport (STL)plane plane YYZ - STL
    7h 52m
    $113–522

  9. Bus to Cleveland-Hopkins International Airport, fly to Lambert–St. Louis International Airport

    1. Take the bus from Buffalo to Cleveland Bus Stationbus bus
    2. Fly from Cleveland-Hopkins International Airport (CLE) to Lambert–St. Louis International Airport (STL)plane plane CLE - STL
    6h 52m
    $527–955

Buffalo to Missouri by train and tram (Amtrak)

Calendar14Weekly Services
Duration20h 25mAverage Duration
Ticket$242Cheapest Price
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Comparing Your Travel Options

Map of how to get from Buffalo to Missouri.ExpandLaunch map view
  • Distance: 699.1 mi
  • Duration: 6h 14m

What companies run services between Buffalo, NY, USA and Missouri, USA?

Southwest Airlines, Delta, and two other airlines fly from Buffalo Niagara International Airport (BUF) to Lambert–St. Louis International Airport (STL) hourly. Alternatively, you can take a train from Buffalo to Metro Center via Buffalo Depew Station, Chicago Union Station, Kansas City, and Union Station in around 20h 25m.

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