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How to get fromChicago to Gainesvilleby plane, bus (Greyhound, Flixbus), train, bus, or car

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There are 8 ways to get from Chicago to Gainesville by plane, bus (Greyhound, Flixbus), train, bus, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Chicago O'Hare International Airport to Gainesville Regional Airport

    best
    1. Fly from Chicago O'Hare International Airport (ORD) to Gainesville Regional Airport (GNV)plane plane ORD - GNV
    7h 55m
    $90–437

  2. Bus

    1. Take the bus from Chicago Bus Station to Atlanta Bus Stationbus bus Greyhound US0100
    2. Take the bus from Atlanta Bus Station to Gainesvillebus bus FlixBus N2401 / ...
    22h 15m
    $148–278

  3. Train, bus

    1. Take the train from Chicago Union Station to Jacksonvilletrain train Floridian
    2. Take the bus from Jacksonville to Gainesvillebus bus FlixBus 2431
    38h 15m
    $523–1,017

  4. Drive 998 mi

    1. Drive from Chicago to Gainesvillecar car 998 mi
    18h
    $183–264

  5. Fly Chicago Midway International Airport to Gainesville Regional Airport

    1. Fly from Chicago Midway International Airport (MDW) to Gainesville Regional Airport (GNV)plane plane MDW - GNV
    7h 3m
    $114–607

  6. Fly Chicago Midway International Airport to Jacksonville, bus

    1. Fly from Chicago Midway International Airport (MDW) to Jacksonville (JAX)plane plane MDW - JAX
    2. Take the bus from Jacksonville to Gainesvillebus bus
    7h 56m
    $142–675

  7. Fly Chicago O'Hare International Airport to Jacksonville, bus

    1. Fly from Chicago O'Hare International Airport (ORD) to Jacksonville (JAX)plane plane ORD - JAX
    2. Take the bus from Jacksonville to Gainesvillebus bus
    8h 20m
    $108–515

  8. Fly Chicago Midway International Airport to Orlando, bus

    1. Fly from Chicago Midway International Airport (MDW) to Orlando (MCO)plane plane MDW - MCO
    2. Take the bus from Orlando - RedCoach Station, FL to Gainesville - Commuter Lot Parking Garage @ Gale Lemerandbus bus
    7h 46m
    $234–552

Chicago to Gainesville by bus

Calendar27Weekly Buses
Duration22h 15mAverage Duration
Ticket$148Cheapest Price
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Questions & Answers

Map of how to get from Chicago to Gainesville.ExpandLaunch map view
  • Distance: 930.4 mi
  • Duration: 7h 55m

What companies run services between Chicago, IL, USA and Gainesville, FL, USA?

Delta and American Airlines fly from Chicago O'Hare International Airport (ORD) to Gainesville Regional Airport (GNV) every 3 hours. Alternatively, you can take a bus from Chicago Bus Station to Gainesville via Atlanta Bus Station in around 22h 15m.

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