There are 9 ways to get from Chicago to Gainesville by plane, bus (Flixbus, Greyhound), train, bus, car, or bus (Greyhound)
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Fly Chicago O'Hare International Airport to Gainesville Regional Airport
best- Fly from Chicago O'Hare International Airport (ORD) to Gainesville Regional Airport (GNV)ORD - GNV
7h 52m$74–387Bus
- Take the bus from Chicago Bus Station to Atlanta Bus StationFlixBus 2512 / ...
- Take the bus from Atlanta Bus Station to GainesvilleFlixBus 2415 / ...
21h 20m$118–288Train, bus
- Take the train from Chicago Union Station to JacksonvilleFloridian
- Take the bus from Jacksonville to GainesvilleFlixBus 2431
38h 9m$206–674Drive 998 mi
- Drive from Chicago to Gainesville998 mi
17h 49m$183–264Fly Chicago Midway International Airport to Gainesville Regional Airport
- Fly from Chicago Midway International Airport (MDW) to Gainesville Regional Airport (GNV)MDW - GNV
7h 3m$94–477Fly Chicago Midway International Airport to Jacksonville, bus
- Fly from Chicago Midway International Airport (MDW) to Jacksonville (JAX)MDW - JAX
- Take the bus from Jacksonville to Gainesville
7h 49m$140–682Fly Chicago O'Hare International Airport to Jacksonville, bus
- Fly from Chicago O'Hare International Airport (ORD) to Jacksonville (JAX)ORD - JAX
- Take the bus from Jacksonville to Gainesville
8h 15m$116–532Fly Chicago Midway International Airport to Orlando, bus
- Fly from Chicago Midway International Airport (MDW) to Orlando (MCO)MDW - MCO
- Take the bus from Orlando RedCoach Station to Gainesville
7h 21m$94–487Bus via North Walmart Supercenter (Greyhound)
- Take the bus from Chicago Train Station to Atlanta Bus StationGreyhound US0100
- Take the bus from Atlanta Bus Station to Gainesville Bus StopGreyhound US0630
23h 53m$125–283
Chicago to Gainesville by bus
Questions & Answers
The cheapest way to get from Chicago to Gainesville is to bus which costs $110 - $290 and takes 21h 20m.
The fastest way to get from Chicago to Gainesville is to fly which takes 7h 3m and costs $90 - $480.
No, there is no direct bus from Chicago station to Gainesville. However, there are services departing from Chicago Bus Station and arriving at Gainesville via Atlanta Bus Station. The journey, including transfers, takes approximately 21h 20m.
The distance between Chicago and Gainesville is 936 miles. The road distance is 1003.9 miles.
The best way to get from Chicago to Gainesville without a car is to bus which takes 21h 20m and costs $110 - $290.
It takes approximately 7h 52m to get from Chicago to Gainesville, including transfers.
Chicago to Gainesville bus services, operated by Flixbus USA, depart from Chicago Bus Station.
The best way to get from Chicago to Gainesville is to fly which takes 7h 52m and costs $70 - $390. Alternatively, you can bus, which costs $110 - $290 and takes 21h 20m.
Chicago to Gainesville bus services, operated by Flixbus USA, arrive at Atlanta Bus Station.
Gainesville is 1h ahead of Chicago. It is currently 7:15 AM in Chicago and 8:15 AM in Gainesville.
What companies run services between Chicago, IL, USA and Gainesville, FL, USA?
American Airlines and Delta fly from Chicago O'Hare International Airport (ORD) to Gainesville Regional Airport (GNV) hourly. Alternatively, you can take a bus from Chicago Bus Station to Gainesville via Atlanta Bus Station in around 21h 20m.
- Website
- southwest.com
Flights from Chicago Midway International Airport to Jacksonville
- Ave. Duration
- 2h 15m
- When
- Every day
- Estimated price
- $120–650
Flights from Chicago Midway International Airport to Jacksonville via Nashville
- Ave. Duration
- 4h 28m
- When
- Monday, Tuesday, Friday, Saturday, and Sunday
- Estimated price
- $120–650
Flights from Chicago O'Hare International Airport to Jacksonville via Nashville
- Ave. Duration
- 4h 55m
- When
- Monday
- Estimated price
- $95–500
Flights from Chicago Midway International Airport to Orlando
- Ave. Duration
- 2h 36m
- When
- Every day
- Estimated price
- $85–440
Flights from Chicago Midway International Airport to Orlando via Birmingham
- Ave. Duration
- 4h 15m
- When
- Monday, Tuesday, Friday, and Sunday
- Estimated price
- $90–450
- Website
- delta.com
Flights from Chicago O'Hare International Airport to Gainesville Regional Airport via Atlanta
- Ave. Duration
- 5h 36m
- When
- Every day
- Estimated price
- $70–380
Flights from Chicago Midway International Airport to Gainesville Regional Airport via Atlanta
- Ave. Duration
- 4h 57m
- When
- Every day
- Estimated price
- $90–470
Flights from Chicago Midway International Airport to Jacksonville via Atlanta
- Ave. Duration
- 4h 58m
- When
- Every day
- Estimated price
- $120–650
Flights from Chicago O'Hare International Airport to Jacksonville via Atlanta
- Ave. Duration
- 4h 40m
- When
- Every day
- Estimated price
- $95–500
- Website
- aa.com
Flights from Chicago O'Hare International Airport to Gainesville Regional Airport via Charlotte
- Ave. Duration
- 5h 24m
- When
- Every day
- Estimated price
- $75–390
Flights from Chicago O'Hare International Airport to Gainesville Regional Airport via Miami
- Ave. Duration
- 6h 10m
- When
- Every day
- Estimated price
- $100–470
Flights from Chicago O'Hare International Airport to Gainesville Regional Airport via Dallas/Ft.Worth
- Ave. Duration
- 6h 26m
- When
- Every day
- Estimated price
- $110–550
Flights from Chicago O'Hare International Airport to Jacksonville
- Ave. Duration
- 2h 32m
- When
- Every day
- Estimated price
- $95–500
- Website
- united.com
Flights from Chicago O'Hare International Airport to Jacksonville
- Ave. Duration
- 2h 36m
- When
- Every day
- Estimated price
- $95–500
- Website
- volaris.com
Flights from Chicago Midway International Airport to Orlando
- Ave. Duration
- 2h 45m
- When
- Every day
- Estimated price
- $75–440
- Website
- allegiantair.com
Flights from Chicago Midway International Airport to Jacksonville via Knoxville
- Ave. Duration
- 5h 5m
- When
- Thursday
- Estimated price
- $120–650
- Website
- flyfrontier.com
Flights from Chicago Midway International Airport to Orlando
- Ave. Duration
- 2h 45m
- When
- Every day
- Estimated price
- $85–440
Rome2Rio's guide to Amtrak
Contact Details
- Phone
- +1 800-872-7245
- Website
- amtrak.com
Train from Chicago Union Station to Jacksonville
- Ave. Duration
- 34h 45m
- Frequency
- Once daily
- Estimated price
- $180–650
- Website
- https://www.amtrak.com/home.html
- Phone
- +1 (855) 626-8585
- Website
- flixbus.com
Bus from Chicago Bus Station to Atlanta Bus Station
- Ave. Duration
- 14h 25m
- Frequency
- 3 times a day
- Estimated price
- $85–190
- Schedules at
- flixbus.com
Bus from Atlanta Bus Station to Gainesville
- Ave. Duration
- 5h 55m
- Frequency
- 4 times a day
- Estimated price
- $40–85
- Schedules at
- flixbus.com
Bus from Jacksonville to Gainesville
- Ave. Duration
- 1h 30m
- Frequency
- 6 times a week
- Estimated price
- $17–24
- Schedules at
- flixbus.com
Rome2Rio's guide to Greyhound USA
Contact Details
- Phone
- +1 214-849-8100
- ifsr@greyhound.com
- Website
- greyhound.com
Bus from Chicago Bus Station to Atlanta Bus Station
- Ave. Duration
- 16h 15m
- Frequency
- 4 times a day
- Estimated price
- $75–210
- Website
- https://www.greyhound.com/
Bus from Chicago Train Station to Atlanta Bus Station
- Ave. Duration
- 15h 55m
- Frequency
- Twice daily
- Estimated price
- $75–210
- Website
- https://www.greyhound.com/
Bus from Atlanta Bus Station to Gainesville Bus Stop
- Ave. Duration
- 5h 35m
- Frequency
- Once daily
- Estimated price
- $45–80
- Website
- https://www.greyhound.com/
- Phone
- +1 877 733 0724
- Website
- redcoachusa.com
Bus from Orlando RedCoach Station to Gainesville
- Ave. Duration
- 1h 55m
- Frequency
- Every 4 hours
- Estimated price
- $14–60
- Website
- https://www.redcoachusa.com
- Web
- $14–60
Want to know more about travelling around United States
Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.
Related travel guides
Travelling to the US: What do I need to know?
Read the travel guide
Need to know: Greyhound
Read the travel guide
Why you should take the train in the US
Read the travel guide
More Questions & Answers
Yes, the driving distance between Chicago to Gainesville is 1004 miles. It takes approximately 17h 49m to drive from Chicago to Gainesville.
Book your Chicago to Gainesville bus tickets online with Omio and FlixBus.
There are 238+ hotels available in Gainesville.











