There are 9 ways to get from Chicago to Gainesville by plane, bus (Greyhound, Flixbus), train, bus, car, or bus (Greyhound)
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Fly Chicago Midway International Airport to Gainesville Regional Airport
best- Fly from Chicago Midway International Airport (MDW) to Gainesville Regional Airport (GNV)plane MDW - GNV
6h 59m$124–607Fly Chicago O'Hare International Airport to Gainesville Regional Airport
cheapest- Fly from Chicago O'Hare International Airport (ORD) to Gainesville Regional Airport (GNV)plane ORD - GNV
7h 54m$84–417Bus
- Take the bus from Chicago Bus Station to Atlanta Bus Stationbus Greyhound US0100
- Take the bus from Atlanta Bus Station to Gainesvillebus FlixBus N2401 / ...
22h 15m$136–303Train, bus
- Take the train from Chicago Union Station to Jacksonvilletrain Floridian
- Take the bus from Jacksonville to Gainesvillebus FlixBus 2431
38h 16m$457–976Drive 998 mi
- Drive from Chicago to Gainesvillecar 998 mi
18h$183–264Fly Chicago Midway International Airport to Jacksonville, bus
- Fly from Chicago Midway International Airport (MDW) to Jacksonville (JAX)plane MDW - JAX
- Take the bus from Jacksonville to Gainesvillebus
7h 49m$162–824Fly Chicago O'Hare International Airport to Jacksonville, bus
- Fly from Chicago O'Hare International Airport (ORD) to Jacksonville (JAX)plane ORD - JAX
- Take the bus from Jacksonville to Gainesvillebus
8h 15m$112–574Fly Chicago Midway International Airport to Orlando, bus
- Fly from Chicago Midway International Airport (MDW) to Orlando (MCO)plane MDW - MCO
- Take the bus from Orlando RedCoach Station to Gainesvillebus
7h 18m$144–617Bus via North Walmart Supercenter (Greyhound)
- Take the bus from Chicago Train Station to Atlanta Bus Stationbus Greyhound US0100
- Take the bus from Atlanta Bus Station to Gainesville Bus Stopbus Greyhound US0630
25h 13m$176–340
Chicago to Gainesville by bus
Questions & Answers
The cheapest way to get from Chicago to Gainesville is to bus which costs $130 - $310 and takes 22h 15m.
The fastest way to get from Chicago to Gainesville is to fly which takes 6h 59m and costs $120 - $650.
No, there is no direct bus from Chicago station to Gainesville. However, there are services departing from Chicago Bus Station and arriving at Gainesville via Atlanta Bus Station. The journey, including transfers, takes approximately 22h 15m.
The distance between Chicago and Gainesville is 913 miles. The road distance is 1003.9 miles.
The best way to get from Chicago to Gainesville without a car is to bus which takes 22h 15m and costs $130 - $310.
It takes approximately 6h 59m to get from Chicago to Gainesville, including transfers.
Chicago to Gainesville bus services, operated by Greyhound USA, depart from Chicago Bus Station.
The best way to get from Chicago to Gainesville is to fly which takes 6h 59m and costs $120 - $650. Alternatively, you can bus, which costs $130 - $310 and takes 22h 15m.
Chicago to Gainesville bus services, operated by Greyhound USA, arrive at Atlanta Bus Station.
Gainesville is 1h ahead of Chicago. It is currently 4:31 AM in Chicago and 5:31 AM in Gainesville.
What companies run services between Chicago, IL, USA and Gainesville, FL, USA?
Delta, Southwest Airlines, and American Airlines fly from Chicago Midway International Airport (MDW) to Gainesville Regional Airport (GNV) 4 times a day. Alternatively, you can take a bus from Chicago Bus Station to Gainesville via Atlanta Bus Station in around 22h 15m.
- Website
- southwest.com
Flights from Chicago Midway International Airport to Jacksonville
- Ave. Duration
- 2h 17m
- When
- Every day
- Estimated price
- $150–800
Flights from Chicago Midway International Airport to Jacksonville via Nashville
- Ave. Duration
- 4h 26m
- When
- Monday, Thursday, Friday, Sunday, Tuesday, and Wednesday
- Estimated price
- $160–850
Flights from Chicago Midway International Airport to Jacksonville via St. Louis
- Ave. Duration
- 4h 35m
- When
- Monday, Thursday, and Friday
- Estimated price
- $170–900
Flights from Chicago Midway International Airport to Orlando
- Ave. Duration
- 2h 37m
- When
- Every day
- Estimated price
- $110–550
Flights from Chicago Midway International Airport to Orlando via Nashville
- Ave. Duration
- 4h 23m
- When
- Every day
- Estimated price
- $110–600
- Website
- delta.com
Flights from Chicago Midway International Airport to Gainesville Regional Airport via Atlanta
- Ave. Duration
- 4h 39m
- When
- Every day
- Estimated price
- $120–600
Flights from Chicago O'Hare International Airport to Gainesville Regional Airport via Atlanta
- Ave. Duration
- 5h 23m
- When
- Every day
- Estimated price
- $80–410
Flights from Chicago Midway International Airport to Jacksonville via Atlanta
- Ave. Duration
- 4h 39m
- When
- Every day
- Estimated price
- $150–800
Flights from Chicago O'Hare International Airport to Jacksonville via Atlanta
- Ave. Duration
- 4h 27m
- When
- Every day
- Estimated price
- $100–550
- Website
- aa.com
Flights from Chicago Midway International Airport to Gainesville Regional Airport via Charlotte
- Ave. Duration
- 4h 45m
- When
- Tuesday and Wednesday
- Estimated price
- $120–650
Flights from Chicago O'Hare International Airport to Gainesville Regional Airport via Charlotte
- Ave. Duration
- 5h 40m
- When
- Every day
- Estimated price
- $85–430
Flights from Chicago O'Hare International Airport to Gainesville Regional Airport via Dallas/Ft.Worth
- Ave. Duration
- 6h 32m
- When
- Every day
- Estimated price
- $130–600
Flights from Chicago O'Hare International Airport to Gainesville Regional Airport via Miami
- Ave. Duration
- 7h
- When
- Every day
- Estimated price
- $120–550
Flights from Chicago O'Hare International Airport to Jacksonville
- Ave. Duration
- 2h 29m
- When
- Every day
- Estimated price
- $100–550
- Website
- united.com
Flights from Chicago O'Hare International Airport to Jacksonville
- Ave. Duration
- 2h 43m
- When
- Every day
- Estimated price
- $100–550
- Website
- flyfrontier.com
Flights from Chicago Midway International Airport to Jacksonville via Atlanta
- Ave. Duration
- 4h 36m
- When
- Every day
- Estimated price
- $150–800
Rome2Rio's guide to Amtrak
Contact Details
- Phone
- +1 800-872-7245
- Website
- amtrak.com
Train from Chicago Union Station to Jacksonville
- Ave. Duration
- 34h 52m
- Frequency
- Once daily
- Estimated price
- $440–1,000
- Website
- https://www.amtrak.com/home.html
Rome2Rio's guide to Greyhound USA
Contact Details
- Phone
- +1 214-849-8100
- ifsr@greyhound.com
- Website
- greyhound.com
Bus from Chicago Bus Station to Atlanta Bus Station
- Ave. Duration
- 16h 5m
- Frequency
- 4 times a day
- Estimated price
- $110–230
- Website
- https://www.greyhound.com/
Bus from Chicago Train Station to Atlanta Bus Station
- Ave. Duration
- 16h 5m
- Frequency
- Twice daily
- Estimated price
- $110–230
- Website
- https://www.greyhound.com/
Bus from Atlanta Bus Station to Gainesville Bus Stop
- Ave. Duration
- 6h 45m
- Frequency
- Once daily
- Estimated price
- $55–110
- Website
- https://www.greyhound.com/
- Phone
- +1 (855) 626-8585
- Website
- https://www.flixbus.com
Bus from Chicago Bus Station to Atlanta Bus Station
- Ave. Duration
- 14h 25m
- Frequency
- Twice daily
- Estimated price
- $95–160
- Schedules at
- flixbus.com
Bus from Atlanta Bus Station to Gainesville
- Ave. Duration
- 5h 10m
- Frequency
- 4 times a day
- Estimated price
- $40–75
- Schedules at
- flixbus.com
Bus from Jacksonville to Gainesville
- Ave. Duration
- 1h 30m
- Frequency
- 6 times a week
- Estimated price
- $9–16
- Schedules at
- flixbus.com
- Phone
- +1 877 733 0724
- Website
- redcoachusa.com
Bus from Orlando RedCoach Station to Gainesville
- Ave. Duration
- 1h 55m
- Frequency
- Every 4 hours
- Estimated price
- $30–60
- Website
- https://www.redcoachusa.com
Want to know more about travelling around United States
Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.
Related travel guides
Travelling to the US: What do I need to know?
Read the travel guide
Need to know: Greyhound
Read the travel guide
Why you should take the train in the US
Read the travel guide
More Questions & Answers
Yes, the driving distance between Chicago to Gainesville is 1004 miles. It takes approximately 18h to drive from Chicago to Gainesville.
Book your Chicago to Gainesville bus tickets online with Omio and FlixBus.
There are 199+ hotels available in Gainesville.










