• Our partners include:

  • Greyhound USA
  • VIA Rail
  • Amtrak
  • Acela Express
  • Megabus
  • SuperShuttle
  • Booking.com
  • Skyscanner
  • Airbnb
  • Expedia

There are 2 ways to get from Sanford to Gainesville by train, bus or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2rio's travel planner.

Recommended option

Train, Megabus  •  4h 12m

  1. Take the train from Sanford to LYNX Central SunRail
  2. Take the Megabus from Orlando to Gainesville

$19 - $30

1 alternative option

Drive  •  2h 14m

  1. Drive from Sanford to Gainesville 113.6 miles

$11 - $17

Questions & Answers

The cheapest way to get from Sanford to Gainesville is to drive which costs $11 - $17 and takes 2h 14m.

More details

The quickest way to get from Sanford to Gainesville is to drive which costs $11 - $17 and takes 2h 14m.

More details

The distance between Sanford and Gainesville is 87 miles. The road distance is 113.6 miles.

Get driving directions

The best way to get from Sanford to Gainesville without a car is to train and Megabus which takes 4h 12m and costs $18 - $30.

More details

It takes approximately 4h 12m to get from Sanford to Gainesville, including transfers.

More details

Yes, the driving distance between Sanford to Gainesville is 114 miles. It takes approximately 2h 14m to drive from Sanford to Gainesville.

Get driving directions

There are 52+ hotels available in Gainesville. Prices start at $59 USD per night.

More details

Map of how to get from Sanford to Gainesville.
Launch map view
  • Distance: 87 miles
  • Duration: 4h 12m

What companies run services between Sanford, FL, USA and Gainesville, FL, USA?

There is no direct connection from Sanford to Gainesville. However, you can take the train to LYNX Central, take the walk to Lynx Central Station - Sunrail, take the line 104 bus to E Colonial Drive And N Semoran Boulevard, take the walk to Orlando, then take the Megabus to Gainesville. Alternatively, you can take the drive to Gainesville.

Train operators
Train from Sanford to LYNX Central
Ave. Duration
Estimated price
$2 - $4
Schedules at
Bus operators

Want to know more about travelling around United States

Rome2rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.