There are 7 ways to get from Chicago to Louisville by plane, bus, train or car
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2rio's travel planner.
Recommended option
Fly Chicago Midway to Louisville • 3 h 40 min
$153 - $247
Cheapest option
Bus • 6 h 10 min
$29 - $80
5 alternative options
Fly Chicago O'Hare to Louisville • 4 h 3 min
$103 - $238
Fly Chicago O'Hare to Lexington, bus • 5 h 26 min
$220 - $740
Train, bus • 8 h 53 min
$53 - $121
Train, bus via Louisville, KY • 9 h 24 min
$71 - $143
Drive • 4 h 53 min
$29 - $45
Questions & Answers
The cheapest way to get from Chicago to Louisville is to drive which costs $29 - $45 and takes 4 h 53 min.
The quickest way to get from Chicago to Louisville is to fly which costs $150 - $250 and takes 3 h 40 min.
Yes, there is a direct bus departing from Chicago and arriving at Louisville, KY. Services depart four times a day, and operate every day. The journey takes approximately 6 h 10 min.
The distance between Chicago and Louisville is 271 miles. The road distance is 296.3 miles.
The best way to get from Chicago to Louisville without a car is to bus which takes 6 h 10 min and costs $29 - $80.
It takes approximately 3 h 40 min to get from Chicago to Louisville, including transfers.
Chicago to Louisville bus services, operated by Megabus, depart from Chicago station.
The best way to get from Chicago to Louisville is to fly which takes 3 h 40 min and costs $150 - $250. Alternatively, you can bus, which costs $29 - $80 and takes 6 h 10 min.
The quickest flight from Chicago Midway Airport to Louisville Airport is the direct flight which takes 1 h 5 min.
Chicago to Louisville bus services, operated by Megabus, arrive at Louisville, KY station.
- Distance: 270.6 miles
- Duration: 3 h 40 min
What companies run services between Chicago, IL, USA and Louisville, KY, USA?
Southwest Airlines flies from Chicago to Louisville 5 times a day. Alternatively, Megabus operates a bus from Chicago to Louisville twice daily. Tickets cost $29 - $40 and the journey takes 6 h 10 min. Three other operators also service this route.
- Website
- united.com
Flights from Chicago O'Hare to Louisville
- Ave. Duration
- 1 h 24 min
- When
- Every day
- Estimated price
- $190 - $440
Flights from Chicago O'Hare to Lexington
- Ave. Duration
- 1 h 23 min
- When
- Every day
- Estimated price
- $300 - $700
- Website
- aa.com
Flights from Chicago O'Hare to Louisville
- Ave. Duration
- 1 h 20 min
- When
- Every day
- Estimated price
- $190 - $440
Flights from Chicago O'Hare to Lexington
- Ave. Duration
- 1 h 16 min
- When
- Every day
- Estimated price
- $300 - $650
- Website
- southwest.com
Flights from Chicago Midway to Louisville
- Ave. Duration
- 1 h 9 min
- When
- Every day
- Estimated price
- $260 - $550
Amtrak is a rail service that connects the US and three Canadian provinces. Covering 21,000 route miles (34,000km) Amtrak operates more than 300 trains daily. These medium and long distance intercity services operate at speeds of up to 240km/h, to more than 500 destinations. Founded in 1971, it is based in Washington, D.C. and offers four classes of travel: First Class, Sleeper, Business and Coach. Ticket fares are divided into five subclasses: Saver, Value, Flexible, Business and Premium. Amtrak trains are known for their wide seats, plug-in power, big windows and storage capabilities.
Rome2rio's guide to Amtrak
Contact Details
- Phone
- +1 215-856-7924
- Website
- amtrak.com
Train from Chicago Union Station to Indianapolis Amtrak Station
- Ave. Duration
- 4 h 54 min
- Frequency
- Once daily
- Estimated price
- $40 - $100
- Website
- amtrak.com
- Coach Seat
- $40 - $60
- Flexi Coach Seat
- $70 - $110
- Business Coach Seat
- $70 - $100
- Room
- $200 - $280
- Phone
- 800-544-2383
- Website
- hoosierride.com
Bus from Lexington, KY to Louisville, KY
- Ave. Duration
- 1 h 20 min
- Frequency
- 4 times a day
- Estimated price
- $21 - $100
- Book at
- hoosierride.com
Bus from Chicago, IL to Louisville, KY
- Ave. Duration
- 8 h
- Frequency
- Once daily
- Estimated price
- $60 - $80
- Book at
- hoosierride.com
Bus from Indianapolis, IN to Louisville, KY
- Ave. Duration
- 3 h 30 min
- Frequency
- Once daily
- Estimated price
- $30 - $45
- Book at
- hoosierride.com
- Phone
- 877-462-6342
- Website
- us.megabus.com
Bus from Chicago to Louisville, KY
- Ave. Duration
- 6 h 10 min
- Frequency
- Twice daily
- Estimated price
- $29 - $40
- Book at
- megabus.com
Bus from Delaware St & Market St Indianapolis to Louisville, KY
- Ave. Duration
- 2 h 45 min
- Frequency
- Twice daily
- Estimated price
- $12 - $23
- Book at
- megabus.com
Amtrak is a rail service that connects the US and three Canadian provinces. Covering 21,000 route miles (34,000km) Amtrak operates more than 300 trains daily. These medium and long distance intercity services operate at speeds of up to 240km/h, to more than 500 destinations. Founded in 1971, it is based in Washington, D.C. and offers four classes of travel: First Class, Sleeper, Business and Coach. Ticket fares are divided into five subclasses: Saver, Value, Flexible, Business and Premium. Amtrak trains are known for their wide seats, plug-in power, big windows and storage capabilities.
Rome2rio's guide to Amtrak
Contact Details
- Phone
- +1 215-856-7924
- Website
- amtrak.com
Bus from Chicago, IL to Louisville, KY
- Ave. Duration
- 8 h 5 min
- Frequency
- Twice daily
- Website
- amtrak.com
Greyhound is a leading bus company based in Dallas, Texas, serving over 3800 destinations across North America, Mexico and Canada. Greyhound carries around 18 million passengers a year who travel 5.4 billion miles (8.6 billion km) a year on their fleet of around 1700 vehicles. For travel flexibility, you can board or get off a Greyhound bus at official Greyhound stations, partner stations and curbside stops. There are around 230 Greyhound stations across the US where you can both catch your bus and buy tickets, that are also available on the official website and via the mobile app.
Rome2rio's guide to Greyhound USA
Contact Details
- Phone
- +1 214-849-8100/1-800-231-2222
- ifsr@greyhound.com
- Website
- greyhound.com
Bus from Chicago, Il to Louisville, Ky
- Ave. Duration
- 7 h 10 min
- Frequency
- Once daily
- Estimated price
- $30 - $80
- Website
- greyhound.com
- Economy
- $30 - $55
- Flexible
- $60 - $80
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Read the travel guideMore Questions & Answers
Louisville is 1 h ahead of Chicago. It is currently 9:53 PM in Chicago and 10:53 PM in Louisville.
Yes, the driving distance between Chicago to Louisville is 296 miles. It takes approximately 4 h 53 min to drive from Chicago to Louisville.
Southwest Airlines offers flights from Chicago Midway Airport to Louisville Airport.
Book your Chicago to Louisville bus tickets online with Rome2rio.
There are 192+ hotels available in Louisville. Prices start at $66 USD per night.
The best way to get from Chicago to Chicago Midway Airport is to subway which takes 23 min and costs $2 - $4.