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There are 7 ways to get from Chicago to Louisville by plane, bus, train or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2rio's travel planner.

Recommended option

Fly Chicago Midway to Louisville  •  3 h 40 min

  1. Fly from Chicago Midway (MDW) to Louisville (SDF) MDW - SDF

$153 - $247

Cheapest option

Bus  •  6 h 10 min

  1. Take the bus from Chicago to Louisville, KY 8250 / ...

$29 - $80

5 alternative options

Fly Chicago O'Hare to Louisville  •  4 h 3 min

  1. Fly from Chicago O'Hare (ORD) to Louisville (SDF) ORD - SDF

$103 - $238

Fly Chicago O'Hare to Lexington, bus  •  5 h 26 min

  1. Fly from Chicago O'Hare (ORD) to Lexington (LEX) ORD - LEX
  2. Take the bus from Lexington, KY to Louisville, KY

$220 - $740

Train, bus  •  8 h 53 min

  1. Take the train from Chicago Union Station to Indianapolis Amtrak Station Hoosier State / ...
  2. Take the bus from Delaware St & Market St Indianapolis to Louisville, KY

$53 - $121

Train, bus via Louisville, KY  •  9 h 24 min

  1. Take the train from Chicago Union Station to Indianapolis Amtrak Station Hoosier State / ...
  2. Take the bus from Indianapolis, IN to Louisville, KY Chicago

$71 - $143

Drive  •  4 h 53 min

  1. Drive from Chicago to Louisville 296.3 miles

$29 - $45

Questions & Answers

The cheapest way to get from Chicago to Louisville is to drive which costs $29 - $45 and takes 4 h 53 min.

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The quickest way to get from Chicago to Louisville is to fly which costs $150 - $250 and takes 3 h 40 min.

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Yes, there is a direct bus departing from Chicago and arriving at Louisville, KY. Services depart four times a day, and operate every day. The journey takes approximately 6 h 10 min.

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The distance between Chicago and Louisville is 271 miles. The road distance is 296.3 miles.

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The best way to get from Chicago to Louisville without a car is to bus which takes 6 h 10 min and costs $29 - $80.

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It takes approximately 3 h 40 min to get from Chicago to Louisville, including transfers.

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Chicago to Louisville bus services, operated by Megabus, depart from Chicago station.

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The best way to get from Chicago to Louisville is to fly which takes 3 h 40 min and costs $150 - $250. Alternatively, you can bus, which costs $29 - $80 and takes 6 h 10 min.

Mode details

The quickest flight from Chicago Midway Airport to Louisville Airport is the direct flight which takes 1 h 5 min.

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Chicago to Louisville bus services, operated by Megabus, arrive at Louisville, KY station.

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Map of how to get from Chicago to Louisville.
Launch map view
  • Distance: 270.6 miles
  • Duration: 3 h 40 min

What companies run services between Chicago, IL, USA and Louisville, KY, USA?

Southwest Airlines flies from Chicago to Louisville 5 times a day. Alternatively, Megabus operates a bus from Chicago to Louisville twice daily. Tickets cost $29 - $40 and the journey takes 6 h 10 min. Three other operators also service this route.

Airlines
United Airlines
Website
united.com
Flights from Chicago O'Hare to Louisville
Ave. Duration
1 h 24 min
When
Every day
Estimated price
$190 - $440
Flights from Chicago O'Hare to Lexington
Ave. Duration
1 h 23 min
When
Every day
Estimated price
$300 - $700
American Airlines
Website
aa.com
Flights from Chicago O'Hare to Louisville
Ave. Duration
1 h 20 min
When
Every day
Estimated price
$190 - $440
Flights from Chicago O'Hare to Lexington
Ave. Duration
1 h 16 min
When
Every day
Estimated price
$300 - $650
Southwest Airlines
Website
southwest.com
Flights from Chicago Midway to Louisville
Ave. Duration
1 h 9 min
When
Every day
Estimated price
$260 - $550
Train operators
Amtrak

Amtrak is a rail service that connects the US and three Canadian provinces. Covering 21,000 route miles (34,000km) Amtrak operates more than 300 trains daily. These medium and long distance intercity services operate at speeds of up to 240km/h, to more than 500 destinations. Founded in 1971, it is based in Washington, D.C. and offers four classes of travel: First Class, Sleeper, Business and Coach. Ticket fares are divided into five subclasses: Saver, Value, Flexible, Business and Premium. Amtrak trains are known for their wide seats, plug-in power, big windows and storage capabilities.

Rome2rio's guide to Amtrak
Contact Details
Phone
+1 215-856-7924
Website
amtrak.com
Train from Chicago Union Station to Indianapolis Amtrak Station
Ave. Duration
4 h 54 min
Frequency
Once daily
Estimated price
$40 - $100
Website
amtrak.com
Coach Seat
$40 - $60
Flexi Coach Seat
$70 - $110
Business Coach Seat
$70 - $100
Room
$200 - $280
Bus operators
Hoosier Ride
Phone
800-544-2383
Website
hoosierride.com
Bus from Lexington, KY to Louisville, KY
Ave. Duration
1 h 20 min
Frequency
4 times a day
Estimated price
$21 - $100
Book at
hoosierride.com
Bus from Chicago, IL to Louisville, KY
Ave. Duration
8 h
Frequency
Once daily
Estimated price
$60 - $80
Book at
hoosierride.com
Bus from Indianapolis, IN to Louisville, KY
Ave. Duration
3 h 30 min
Frequency
Once daily
Estimated price
$30 - $45
Book at
hoosierride.com
Megabus
Phone
877-462-6342
Website
us.megabus.com
Bus from Chicago to Louisville, KY
Ave. Duration
6 h 10 min
Frequency
Twice daily
Estimated price
$29 - $40
Book at
megabus.com
Bus from Delaware St & Market St Indianapolis to Louisville, KY
Ave. Duration
2 h 45 min
Frequency
Twice daily
Estimated price
$12 - $23
Book at
megabus.com
Amtrak

Amtrak is a rail service that connects the US and three Canadian provinces. Covering 21,000 route miles (34,000km) Amtrak operates more than 300 trains daily. These medium and long distance intercity services operate at speeds of up to 240km/h, to more than 500 destinations. Founded in 1971, it is based in Washington, D.C. and offers four classes of travel: First Class, Sleeper, Business and Coach. Ticket fares are divided into five subclasses: Saver, Value, Flexible, Business and Premium. Amtrak trains are known for their wide seats, plug-in power, big windows and storage capabilities.

Rome2rio's guide to Amtrak
Contact Details
Phone
+1 215-856-7924
Website
amtrak.com
Bus from Chicago, IL to Louisville, KY
Ave. Duration
8 h 5 min
Frequency
Twice daily
Website
amtrak.com
Greyhound USA

Greyhound is a leading bus company based in Dallas, Texas, serving over 3800 destinations across North America, Mexico and Canada. Greyhound carries around 18 million passengers a year who travel 5.4 billion miles (8.6 billion km) a year on their fleet of around 1700 vehicles. For travel flexibility, you can board or get off a Greyhound bus at official Greyhound stations, partner stations and curbside stops. There are around 230 Greyhound stations across the US where you can both catch your bus and buy tickets, that are also available on the official website and via the mobile app.

Rome2rio's guide to Greyhound USA
Contact Details
Phone
+1 214-849-8100/1-800-231-2222
Email
ifsr@greyhound.com
Website
greyhound.com
Bus from Chicago, Il to Louisville, Ky
Ave. Duration
7 h 10 min
Frequency
Once daily
Estimated price
$30 - $80
Website
greyhound.com
Economy
$30 - $55
Flexible
$60 - $80

Want to know more about travelling around United States

Rome2rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

More Questions & Answers

Louisville is 1 h ahead of Chicago. It is currently 9:53 PM in Chicago and 10:53 PM in Louisville.

Yes, the driving distance between Chicago to Louisville is 296 miles. It takes approximately 4 h 53 min to drive from Chicago to Louisville.

Get driving directions

Southwest Airlines offers flights from Chicago Midway Airport to Louisville Airport.

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Book your Chicago to Louisville bus tickets online with Rome2rio.

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There are 192+ hotels available in Louisville. Prices start at $66 USD per night.

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The best way to get from Chicago to Chicago Midway Airport is to subway which takes 23 min and costs $2 - $4.

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