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There are 6 ways to get from Chicago to Louisville by plane, bus, train or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2rio's travel planner.

Recommended option

Fly from Chicago Midway  •  3h 39m

  1. Fly from Chicago Midway (MDW) to Louisville (SDF) MDW - SDF

Cheapest option

Bus  •  6h 15m

  1. Take the bus from Chicago to Louisville "Greyhound" / ...

4 alternative options

Fly from Chicago O'Hare  •  4h 6m

  1. Fly from Chicago O'Hare (ORD) to Louisville (SDF) ORD - SDF

Bus via Indianapolis  •  6h 28m

  1. Take the bus from Chicago IL to Indianapolis IN Palmland / ...
  2. Take the bus from Indianapolis Amtrak Station to Louisville, KY "Greyhound" / ...

Train, bus  •  7h 49m

  1. Take the train from Chicago Union Station to Indianapolis Cardinal
  2. Take the bus from Indianapolis Amtrak Station to Louisville, KY "Greyhound" / ...

Drive  •  4h 56m

  1. Drive from Chicago to Louisville 296.4 miles
Chicago → Louisville
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Travel safe during COVID-19

Rules to follow in United States

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Recommended

Recommended

Travel within United States

Domestic border crossings may be subject to approval, testing and quarantine

COVID-19 help in United States

If you need help, visit the national COVID-19 website or call the COVID-19 Helpline 800-232-4636

Frequently Asked Questions


Yes, travel within United States is currently allowed.

Explore travel options

Domestic travel is not restricted, but some conditions may apply

  • Face masks are recommended
  • There is a social distancing requirement of 2 metres
  • Domestic border crossings may be subject to approval, testing and quarantine

Explore travel options

The national COVID-19 helpline number in Louisville is 800-232-4636.

Wearing a face mask on public transport in Louisville is recommended.

The social distance requirement in Louisville is 2 metres.

Make yourself known to an official member of staff and/or call the national coronavirus helpline number on 800-232-4636.

Last updated: 10 May 2022
Exceptions may apply, for full details: Centers for Disease control and prevention (CDC).

We're working around the clock to bring you the latest COVID-19 travel updates.
This information is compiled from official sources. To the best of our knowledge, it is correct as of the last update.
Visit Rome2rio travel advice for general help.

Questions & Answers

The most affordable way to get from Chicago to Louisville is to drive, which costs $29 - $45 and takes 4h 56m.

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The quickest way to get from Chicago to Louisville is to fly which costs $150 - $600 and takes 3h 39m.

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Yes, there is a direct bus departing from Chicago and arriving at Louisville. Services depart five times a day, and operate every day. The journey takes approximately 6h 15m.

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The distance between Chicago and Louisville is 271 miles. The road distance is 296.4 miles.

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The best way to get from Chicago to Louisville without a car is to bus which takes 6h 15m and costs $23 - $80.

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It takes approximately 3h 39m to get from Chicago to Louisville, including transfers.

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Chicago to Louisville bus services, operated by Greyhound USA, depart from Chicago station.

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The best way to get from Chicago to Louisville is to fly which takes 3h 39m and costs $150 - $600. Alternatively, you can bus, which costs $23 - $80 and takes 6h 15m.

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The quickest flight from Chicago Midway Airport to Louisville Airport is the direct flight which takes 1h 5m.

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Chicago to Louisville bus services, operated by Greyhound USA, arrive at Louisville station.

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Map of how to get from Chicago to Louisville.
Launch map view
  • Distance: 270.6 miles
  • Duration: 3h 39m

What companies run services between Chicago, IL, USA and Louisville, KY, USA?

Southwest Airlines flies from Chicago to Louisville 3 times a day. Alternatively, Greyhound USA operates a bus from Chicago to Louisville twice daily. Tickets cost $35 - $50 and the journey takes 6h 15m. Two other operators also service this route.

Airlines
Southwest Airlines
Website
southwest.com
Flights from Chicago Midway to Louisville
Ave. Duration
1h 8m
When
Every day
Estimated price
$110 - $370
American Airlines
Website
aa.com
Flights from Chicago O'Hare to Louisville
Ave. Duration
1h 24m
When
Every day
Estimated price
$180 - $460
United Airlines
Website
united.com
Flights from Chicago O'Hare to Louisville
Ave. Duration
1h 26m
When
Every day
Estimated price
$180 - $480
Delta
Website
delta.com
Flights from Chicago O'Hare to Louisville via Detroit
Ave. Duration
3h 32m
When
Every day
Estimated price
$200 - $460
Train operators
Amtrak

Amtrak is a rail service that connects the US and three Canadian provinces. Covering 21,000 route miles (34,000km) Amtrak operates more than 300 trains daily. These medium and long distance intercity services operate at speeds of up to 240km/h, to more than 500 destinations. Founded in 1971, it is based in Washington, D.C. and offers four classes of travel: First Class, Sleeper, Business and Coach. Ticket fares are divided into five subclasses: Saver, Value, Flexible, Business and Premium. Amtrak trains are known for their wide seats, plug-in power, big windows and storage capabilities.

Rome2rio's guide to Amtrak
Contact Details
Phone
+1 800-872-7245
Website
amtrak.com
Train from Chicago Union Station to Indianapolis
Ave. Duration
4h 54m
Frequency
3 times a week
Estimated price
$35 - $55
Website
Amtrak
Coach Seat
$35 - $55
Premium
$200 - $280
Flexi Coach Seat
$60 - $90
Business Seat
$60 - $85
Bus operators
Greyhound USA

Greyhound is a leading bus company based in Dallas, Texas, serving over 3800 destinations across North America, Mexico and Canada. Greyhound carries around 18 million passengers a year who travel 5.4 billion miles (8.6 billion km) a year on their fleet of around 1700 vehicles. For travel flexibility, you can board or get off a Greyhound bus at official Greyhound stations, partner stations and curbside stops. There are around 230 Greyhound stations across the US where you can both catch your bus and buy tickets, that are also available on the official website and via the mobile app.

Rome2rio's guide to Greyhound USA
Contact Details
Phone
+1 214-849-8100/1-800-231-2222
Email
ifsr@greyhound.com
Website
greyhound.com
Bus from Chicago to Louisville
Ave. Duration
6h 15m
Frequency
Twice daily
Estimated price
$35 - $50
Website
greyhound.com
Economy
$35 - $50
Flexible
$60 - $85
Bus from Indianapolis to Louisville
Ave. Duration
2h
Frequency
Twice daily
Estimated price
$18 - $26
Website
greyhound.com
Economy
$18 - $26
Flexible
$35 - $55
Amtrak Thruway

Amtrak is a rail service that connects the US and three Canadian provinces. Covering 21,000 route miles (34,000km) Amtrak operates more than 300 trains daily. These medium and long distance intercity services operate at speeds of up to 240km/h, to more than 500 destinations. Founded in 1971, it is based in Washington, D.C. and offers four classes of travel: First Class, Sleeper, Business and Coach. Ticket fares are divided into five subclasses: Saver, Value, Flexible, Business and Premium. Amtrak trains are known for their wide seats, plug-in power, big windows and storage capabilities.

Rome2rio's guide to Amtrak Thruway
Contact Details
Phone
+1 800-872-7245
Website
amtrak.com
Bus from Chicago Union Station to Louisville, KY
Ave. Duration
7h 5m
Frequency
Twice daily
Estimated price
$23 - $65
Schedules at
amtrak.com
Child 2-12
$23 - $35
Adult
$45 - $65
Bus from Indianapolis Amtrak Station to Louisville, KY
Ave. Duration
1h 55m
Frequency
Twice daily
Estimated price
$11 - $35
Schedules at
amtrak.com
Child 2-12
$11 - $17
Adult
$23 - $35
Hoosier Ride
Phone
+1 800-544-2383
Website
hoosierride.com
Bus from Chicago, IL to Louisville, KY
Ave. Duration
8h
Frequency
Once daily
Estimated price
$40 - $80
Book at
hoosierride.com
Child Fares
$40 - $60
Bus from Indianapolis, IN to Louisville, KY
Ave. Duration
3h 30m
Frequency
Once daily
Estimated price
$19 - $40
Book at
hoosierride.com
Child Fares
$19 - $27
Palmland Bus Lines
Website
palmlandlines.com
Bus from Chicago IL to Indianapolis IN
Ave. Duration
3h 20m
Frequency
Hourly
Estimated price
$50 - $65
Schedules at
palmlandlines.com
Flixbus USA
Phone
(855) 626-8585
Website
flixbus.com
Bus from Chicago to Indianapolis
Ave. Duration
3h 30m
Frequency
Once daily
Estimated price
$15 - $55
Schedules at
flixbus.com
Adult Standard Purchase
$20 - $55
Adult Advance Purchase
$15 - $21
OurBus
Phone
+1 844-800-6828
Email
pr@ourbus.com
Website
ourbus.com
Bus from Chicago, IL to Indianapolis, IN
Ave. Duration
4h 55m
Frequency
5 times a week
Estimated price
$26 - $35
Book at
ourbus.com

Want to know more about travelling around United States

Rome2rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

More Questions & Answers

Louisville is 1h ahead of Chicago. It is currently 3:57 PM in Chicago and 4:57 PM in Louisville.

Yes, the driving distance between Chicago to Louisville is 296 miles. It takes approximately 4h 56m to drive from Chicago to Louisville.

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Southwest Airlines offers flights from Chicago Midway Airport to Louisville Airport.

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Book your Chicago to Louisville bus tickets online with Omio and Busbud.

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There are 177+ hotels available in Louisville. Prices start at $100 USD per night.

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The best way to get from Chicago to Chicago Midway Airport is to subway which takes 23 min and costs $1 - $5.

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