There are 5 ways to get from Appleton to Mayo Clinic by bus, car, or plane
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Bus
best- Take the bus from Appleton Valley Transit to La Crosse Grand River Stationbus Green Bay
- Take the bus from La Crosse to Rochesterbus Jefferson 966
7h 13m$42–94Drive 232.6 mi
- Drive from Appleton to Mayo Cliniccar 232.6 mi
4h 30m$43–62Fly Appleton International Airport to Rochester
- Fly from Appleton International Airport (ATW) to Rochester (RST)plane ATW - RST
5h 5m$64–362Fly Appleton International Airport to Minneapolis–Saint Paul International Airport, bus
- Fly from Appleton International Airport (ATW) to Minneapolis–Saint Paul International Airport (MSP)plane ATW - MSP
- Take the bus from Minneapolis / St Paul Airport to Groome Transportation Office - Rochesterbus
4h 16m$135–536Fly Green Bay to Rochester
- Fly from Green Bay (GRB) to Rochester (RST)plane GRB - RST
6h 40m$82–392
Appleton to Mayo Clinic by bus and foot
Questions & Answers
The cheapest way to get from Appleton to Mayo Clinic is to drive which costs $40 - $65 and takes 4h 30m.
The fastest way to get from Appleton to Mayo Clinic is to fly and bus which takes 4h 16m and costs $130 - $550.
No, there is no direct bus from Appleton to Mayo Clinic. However, there are services departing from Appleton Valley Transit and arriving at Rochester via La Crosse. The journey, including transfers, takes approximately 7h 13m.
The distance between Appleton and Mayo Clinic is 259 miles. The road distance is 234 miles.
The best way to get from Appleton to Mayo Clinic without a car is to bus which takes 7h 13m and costs $40 - $95.
It takes approximately 7h 13m to get from Appleton to Mayo Clinic, including transfers.
Appleton to Mayo Clinic bus services, operated by Lamers Bus Lines, depart from Appleton Valley Transit station.
The best way to get from Appleton to Mayo Clinic is to bus which takes 7h 13m and costs $40 - $95. Alternatively, you can fly, which costs $60 - $370 and takes 5h 5m.
Appleton to Mayo Clinic bus services, operated by Lamers Bus Lines, arrive at La Crosse Grand River Station.
Yes, the driving distance between Appleton to Mayo Clinic is 234 miles. It takes approximately 4h 30m to drive from Appleton to Mayo Clinic.
What companies run services between Appleton, WI, USA and Mayo Clinic, MN, USA?
You can take a bus from Appleton Valley Transit to Mayo Clinic via La Crosse Grand River Station, La Crosse, and Rochester in around 7h 13m. Alternatively, Delta, United Airlines, and American Airlines fly from Appleton International Airport (ATW) to Rochester (RST) 5 times a day.
- Website
- delta.com
Flights from Appleton International Airport to Rochester via Minneapolis–Saint Paul International Airport
- Ave. Duration
- 4h 49m
- When
- Every day
- Estimated price
- $45–300
Flights from Appleton International Airport to Minneapolis–Saint Paul International Airport
- Ave. Duration
- 1h 19m
- When
- Every day
- Estimated price
- $65–460
Flights from Green Bay to Rochester via Minneapolis–Saint Paul International Airport
- Ave. Duration
- 4h 59m
- When
- Every day
- Estimated price
- $45–310
- Website
- aa.com
Flights from Appleton International Airport to Rochester via Chicago O'Hare
- Ave. Duration
- 5h 14m
- When
- Every day
- Estimated price
- $50–320
Flights from Green Bay to Rochester via Chicago O'Hare
- Ave. Duration
- 5h 54m
- When
- Every day
- Estimated price
- $50–330
- Website
- united.com
Flights from Appleton International Airport to Rochester via Chicago O'Hare
- Ave. Duration
- 4h 5m
- When
- Monday, Tuesday, Wednesday, and Sunday
- Estimated price
- $50–320
Flights from Green Bay to Rochester via Chicago O'Hare
- Ave. Duration
- 3h 51m
- When
- Monday, Tuesday, Wednesday, Friday, Saturday, and Sunday
- Estimated price
- $50–330
- Phone
- 920 496 3600
- Website
- golamers.com
Bus from Appleton Valley Transit to La Crosse Grand River Station
- Ave. Duration
- 4h 15m
- Frequency
- Once daily
- Estimated price
- $34–39
- Schedules at
- golamers.com
- Phone
- +1-858-800-8898
- Website
- jeffersonlines.com
Bus from La Crosse to Rochester
- Ave. Duration
- 1h 50m
- Frequency
- Once daily
- Estimated price
- $7–55
- Book at
- https://www.jeffersonlines.com
- Phone
- + 1 507-280-9270
- Website
- groometransportation.com
Bus from Minneapolis / St Paul Airport to Groome Transportation Office - Rochester
- Ave. Duration
- 1h 30m
- Frequency
- Every 4 hours
- Estimated price
- $40–50
- Website
- https://groometransportation.com/minneapolis-st-paul-airport/rochester
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