There are 6 ways to get from Appleton to Saint Charles by plane, bus, train, bus (Greyhound, Flixbus), car, or taxi
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Fly from Appleton International Airport
best- Fly from Appleton International Airport (ATW) to Lambert–St. Louis International Airport (STL)plane ATW - STL
5h 27m$104–491Drive 457.3 mi
cheapest- Drive from Appleton to Saint Charlescar 457.3 mi
7h 50m$84–121Bus, train
- Take the bus from Oshkosh to Milwaukeebus
- Take the train from Milwaukee to Chicago Union Stationtrain
- Take the train from Chicago Union Station to St. Louistrain
11h 59m$283–419Bus
- Take the bus from Oshkosh to Milwaukeebus
- Take the bus from Milwaukee Intermodal Station to Chicago Bus Stationbus
- Take the bus from Chicago Bus Station to St Louis Bus Stationbus
15h 3m$127–185Taxi to Green Bay, fly
- Take the taxi from Appleton to Green Bay (GRB)taxi
- Fly from Green Bay (GRB) to Lambert–St. Louis International Airport (STL)plane GRB - STL
5h 51m$189–591Bus to General Mitchell International Airport, fly
- Take the bus from Oshkosh to Milwaukeebus
- Fly from General Mitchell International Airport (MKE) to Lambert–St. Louis International Airport (STL)plane MKE - STL
6h 22m$569–955
Appleton International Airport (ATW) to Lambert–St. Louis International Airport (STL) flights
Comparing Your Travel Options
The cheapest way to get from Appleton to Saint Charles is to drive which costs $80 - $130 and takes 7h 50m.
The fastest way to get from Appleton to Saint Charles is to fly which takes 5h 27m and costs $100 - $500.
No, there is no direct bus from Appleton to Saint Charles. However, there are services departing from Prospect and Walnut and arriving at 4375 Rider Trail North Sb via Oshkosh, Milwaukee Intermodal Station, Chicago Bus Station, Civic Center Transit Center and North Hanley Transit Center. The journey, including transfers, takes approximately 15h 3m.
The distance between Appleton and Saint Charles is 420 miles. The road distance is 460 miles.
The best way to get from Appleton to Saint Charles without a car is to bus and train which takes 11h 59m and costs $280 - $420.
It takes approximately 5h 27m to get from Appleton to Saint Charles, including transfers.
Appleton to Saint Charles bus services, operated by Lamers Bus Lines, depart from Oshkosh station.
The best way to get from Appleton to Saint Charles is to fly which takes 5h 27m and costs $100 - $500. Alternatively, you can bus, which costs $120 - $190 and takes 15h 3m.
Appleton to Saint Charles bus services, operated by Lamers Bus Lines, arrive at Milwaukee station.
Yes, the driving distance between Appleton to Saint Charles is 460 miles. It takes approximately 7h 50m to drive from Appleton to Saint Charles.
What companies run services between Appleton, WI, USA and Saint Charles, MO, USA?
United Airlines, Delta, and American Airlines fly from Appleton International Airport (ATW) to Lambert–St. Louis International Airport (STL) hourly. Alternatively, you can take a bus from Prospect and Walnut to Saint Charles via Church @ Doty - Neenah Transit Center, Oshkosh, Milwaukee, Milwaukee Intermodal Station, Chicago Bus Station, St Louis Bus Station, Civic Center Transit Center, North Hanley Transit Center, and 4375 Rider Trail North Sb in around 15h 3m.
- Website
- united.com
Flights from Appleton International Airport to Lambert–St. Louis International Airport via Chicago O'Hare
- Ave. Duration
- 4h 18m
- When
- Every day
- Estimated price
- $70–450
Flights from Green Bay to Lambert–St. Louis International Airport via Chicago O'Hare
- Ave. Duration
- 4h 32m
- When
- Every day
- Estimated price
- $70–450
- Website
- delta.com
Flights from Appleton International Airport to Lambert–St. Louis International Airport via Minneapolis
- Ave. Duration
- 4h 49m
- When
- Every day
- Estimated price
- $90–550
Flights from Appleton International Airport to Lambert–St. Louis International Airport via Atlanta
- Ave. Duration
- 5h 16m
- When
- Every day
- Estimated price
- $130–650
Flights from Appleton International Airport to Lambert–St. Louis International Airport via Detroit
- Ave. Duration
- 6h 32m
- When
- Every day
- Estimated price
- $95–550
Flights from Green Bay to Lambert–St. Louis International Airport via Minneapolis
- Ave. Duration
- 5h 5m
- When
- Every day
- Estimated price
- $95–550
Flights from Green Bay to Lambert–St. Louis International Airport via Atlanta
- Ave. Duration
- 5h 15m
- When
- Every day
- Estimated price
- $140–650
Flights from Green Bay to Lambert–St. Louis International Airport via Detroit
- Ave. Duration
- 6h 34m
- When
- Every day
- Estimated price
- $95–550
- Website
- aa.com
Flights from Appleton International Airport to Lambert–St. Louis International Airport via Chicago O'Hare
- Ave. Duration
- 5h 34m
- When
- Every day
- Estimated price
- $70–450
Flights from Appleton International Airport to Lambert–St. Louis International Airport via Dallas/Ft.Worth
- Ave. Duration
- 6h
- When
- Saturday
- Estimated price
- $150–700
Flights from Appleton International Airport to Lambert–St. Louis International Airport via Charlotte
- Ave. Duration
- 7h 40m
- When
- Every day
- Estimated price
- $140–700
Flights from Green Bay to Lambert–St. Louis International Airport via Chicago O'Hare
- Ave. Duration
- 5h 19m
- When
- Every day
- Estimated price
- $70–450
- Website
- southwest.com
Flights from General Mitchell International Airport to Lambert–St. Louis International Airport
- Ave. Duration
- 1h 15m
- When
- Every day
- Estimated price
- $85–600
Flights from General Mitchell International Airport to Lambert–St. Louis International Airport via Chicago Midway
- Ave. Duration
- 3h 16m
- When
- Monday, Thursday, Friday, Tuesday, Wednesday, and Sunday
- Estimated price
- $85–600
Rome2Rio's guide to Amtrak
Contact DetailsContact Details
- Phone
- +1 800-872-7245
- Website
- Amtrak
Train from Milwaukee to Chicago Union Station
- Ave. Duration
- 1h 29m
- Frequency
- Every 4 hours
- Estimated price
- $45–75
- Website
- Amtrak
Train from Chicago Union Station to St. Louis
- Ave. Duration
- 4h 46m
- Frequency
- 5 times a day
- Estimated price
- $150–240
- Website
- Amtrak
- Phone
- 920 496 3600
- Website
- example.com
Bus from Oshkosh to Milwaukee
- Ave. Duration
- 1h 45m
- Frequency
- Once daily
- Estimated price
- $20–23
- Schedules at
- golamers.com
Bus from Oshkosh to Milwaukee
- Ave. Duration
- 1h 45m
- Frequency
- Once daily
- Estimated price
- $20–23
- Schedules at
- golamers.com
Bus from Oshkosh to Milwaukee
- Ave. Duration
- 2h 25m
- Frequency
- Once daily
- Estimated price
- $21–24
- Schedules at
- golamers.com
Rome2Rio's guide to Greyhound USA
Contact DetailsContact Details
- Phone
- +1 214-849-8100
- ifsr@greyhound.com
- Website
- Greyhound
Bus from Milwaukee Intermodal Station to Chicago Bus Station
- Ave. Duration
- 1h 35m
- Frequency
- 4 times a day
- Estimated price
- $15–23
- Website
- Greyhound
- Phone
- +1 (855) 626-8585
- Website
- Flixbus USA
Bus from Milwaukee Intermodal Station to Chicago Bus Station
- Ave. Duration
- 2h 15m
- Frequency
- 3 times a day
- Estimated price
- $13–21
- Schedules at
- Flixbus USA
Bus from Chicago Bus Station to St Louis Bus Station
- Ave. Duration
- 5h 55m
- Frequency
- Twice daily
- Estimated price
- $45–75
- Schedules at
- Flixbus USA
- Ave. Duration
- 41 min
- Estimated price
- $95–120
Able Taxi and Tours
- Phone
- +1 920-265-7760
- Website
- abletaxiandtours.com
Appleton Yellow Taxi
- Phone
- +1 920-733-4444
- Website
- appletonyellowtaxi.com
Fox Valley Cab
- Phone
- +1 920-734-4545
- Website
- facebook.com
Want to know more about travelling around United States
Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.
Related travel guides
Travelling to the US: What do I need to know?
Read the travel guide
Why you should take the train in the US
Read the travel guide
Need to know: Greyhound
Read the travel guide
Booking & Getting There
There are 171+ hotels available in Saint Charles.








