The average train between Siena and Mede takes 8h 56m and the fastest train takes 5h 49m. The train service runs several times per day from Siena to Mede. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run twice daily between Siena and Mede. The earliest departure is at 7:02 AM in the morning, and the last departure from Siena is at 9:40 PM which arrives into Mede at 12:51 PM. All services require a transfer at Firenze S.M.N. and take an average of 8h 56m. The schedules shown below are for the next available departures.



5h 49m • 3 changes



7h 29m • 3 changes



6h 33m • 3 changes



6h 33m • 3 changes
Want to know about travelling from Siena to Mede? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Siena to Mede. However, there are services departing from Siena station and arriving at Mede station via Firenze S.M.N.. The journey, including transfers, takes approximately 8h 56m.
Siena to Mede train services, operated by Trenitalia, depart from Siena station.
Siena to Mede train services, operated by Trenitalia, arrive at Milano Rogoredo station.
Book your Siena to Mede train tickets online with Trenitalia, Trenitalia Frecce and 2 other operators.
The distance between Siena and Mede is 286.2 km. The road distance is 454 km.
You can take a train from Siena to Mede via Firenze S.M.N., Milano Rogoredo, and Pavia in around 5h 51m.