The average train between Rome and Wetzlar takes 17h 59m and the fastest train takes 13h 56m. The train service runs several times per day from Rome to Wetzlar. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run 3 times a day between Rome and Wetzlar. The earliest departure is at 7:30 AM in the morning, and the last departure from Rome is at 8:05 PM which arrives into Wetzlar at 5:26 PM. All services require a transfer at Milano Centrale and take an average of 17h 59m. The schedules shown below are for the next available departures.




13h 56m • 4 changes
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20h 21m • 4 changes
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21h 16m • 4 changes
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21h 21m • 4 changes




13h 56m • 4 changes
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17h 16m • 4 changes
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21h 21m • 4 changes




13h 56m • 4 changes
Arrives next day




17h 16m • 4 changes
Arrives next day




21h 21m • 4 changes




13h 56m • 4 changes
Arrives next day




17h 16m • 4 changes
Arrives next day




21h 21m • 4 changes




13h 56m • 4 changes
Arrives next day




17h 16m • 4 changes
Arrives next day




21h 21m • 4 changes
Want to know about travelling from Rome to Wetzlar? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Rome to Wetzlar. However, there are services departing from Rome station and arriving at Wetzlar station via Milano Centrale. The journey, including transfers, takes approximately 17h 59m.
Rome to Wetzlar train services, operated by ItaloTreno, depart from Roma Termini station.
Rome to Wetzlar train services, operated by ItaloTreno, arrive at Gießen Bahnhof station.
Book your Rome to Wetzlar train tickets online with ItaloTreno, Trenitalia EuroCity and 3 other operators.
The distance between Rome and Wetzlar is 1,010.4 km. The road distance is 1,353 km.
You can take a train from Roma Termini to Wetzlar Bahnhof via Milano Centrale, Basel SBB, Frankfurt, and Gießen Bahnhof in around 14h 24m.