The average train between Rome and Lissone takes 4h 58m and the fastest train takes 4h 1m. The train service runs several times per day from Rome to Lissone. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run every 4 hours between Rome and Lissone. The earliest departure is at 6:30 AM in the morning, and the last departure from Rome is at 8:05 PM which arrives into Lissone at 8:31 AM. All services require a transfer at Milano Centrale and take an average of 4h 58m. The schedules shown below are for the next available departures.


4h 1m • 2 changes


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4h 26m • 2 changes


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4h 26m • 2 changes


4h 1m • 2 changes


4h 1m • 2 changes


4h 26m • 2 changes


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4h 1m • 2 changes


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4h 26m • 2 changes


4h 26m • 2 changes
Want to know about travelling from Rome to Lissone? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Rome to Lissone. However, there are services departing from Rome station and arriving at Lissone station via Milano Centrale. The journey, including transfers, takes approximately 4h 58m.
Rome to Lissone train services, operated by ItaloTreno, depart from Roma Termini station.
Rome to Lissone train services, operated by ItaloTreno, arrive at Milano Centrale station.
Book your Rome to Lissone train tickets online with ItaloTreno, Trenitalia EuroCity and Trenord.
The distance between Rome and Lissone is 488.6 km. The road distance is 597 km.
ItaloTreno operates a train from Roma Termini to Milano Centrale hourly. Tickets cost €70–140 and the journey takes 3h 5m.