Rome2Rio

Prague to Brussels buses

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Trip Overview

The average bus between Prague and Brussels takes 13h 9m and the fastest bus takes 12h. There is at least one bus per day from Prague to Brussels. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

13h 9m
Duration
907 km
Distance
€95
Average price
Once daily
Frequency

Prague to Brussels bus times

Buses run once daily between Prague and Brussels. The earliest departure is at 9:45 AM in the morning, and the last departure from Prague is at 6:00 PM which arrives into Brussels at 6:00 AM. All services run direct with no transfers required, and take on average 13h 9m. The schedules shown below are for the next available departures.

Departing Thursday, November 12, 2026

  •  → 

    bus bus 13h 30m • Direct

Departing Friday, November 13, 2026

  •  → 

    Arrives next day

    bus bus 13h 30m • Direct
  •  → 

    Arrives next day

    bus bus 12h • Direct

Departing Saturday, November 14, 2026

  •  → 

    bus bus 13h 29m • Direct

Departing Sunday, November 15, 2026

  •  → 

    Arrives next day

    bus bus 13h 30m • Direct

Departing Monday, November 16, 2026

  •  → 

    Arrives next day

    bus bus 13h 30m • Direct

Departing Tuesday, November 17, 2026

  •  → 

    Arrives next day

    bus bus 13h 30m • Direct
  •  → 

    Arrives next day

    bus bus 12h • Direct

Departing Wednesday, November 18, 2026

  •  → 

    Arrives next day

    bus bus 13h 30m • Direct

Frequently asked questions

Want to know about travelling from Prague to Brussels? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from Prague to Brussels.ExpandLaunch map view
  • Distance: 907.1 km
  • Duration: 13h 9m

What companies run services between Prague, Czechia and Brussels, Belgium?

FlixBus operates a bus from Praha, ÚAN Florenc to Brussels-North train station once daily. Tickets cost €80–120 and the journey takes 13h 29m. RegioJet also services this route 4 times a week.

Operators