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Pittsburgh to St. Louis trains

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Trip Overview

The train between Pittsburgh and St. Louis takes 15h 52m. The train runs, on average, 6 times per week from Pittsburgh to St. Louis. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

15h 52m
Duration
758 mi
Distance
$489
Average price
6 times a week
Frequency

Pittsburgh to St. Louis train times

Trains run 6 times a week between Pittsburgh and St. Louis. The service departs Pittsburgh at 11:59 PM at night, which arrives into St. Louis at 14:51:00. All services require a transfer, and take on average 15h 52m. The schedules shown below are for the next available departures.

Departing Saturday, November 14, 2026

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    Arrives next day

    AmtrakAmtrak15h 52m • 1 change

Departing Sunday, November 15, 2026

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    Arrives next day

    AmtrakAmtrak15h 52m • 1 change

Departing Monday, November 16, 2026

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    Arrives next day

    AmtrakAmtrak15h 52m • 1 change

Departing Tuesday, November 17, 2026

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    Arrives next day

    AmtrakAmtrak15h 52m • 1 change

Departing Wednesday, November 18, 2026

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    Arrives next day

    AmtrakAmtrak15h 52m • 1 change

Departing Thursday, November 19, 2026

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    Arrives next day

    AmtrakAmtrak15h 52m • 1 change

Frequently asked questions

Want to know about travelling from Pittsburgh to St. Louis? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from Pittsburgh to St. Louis.ExpandLaunch map view
  • Distance: 757.6 mi
  • Duration: 15h 52m

What companies run services between Pittsburgh, PA, USA and St. Louis, MO, USA?

You can take a train from Pittsburgh Amtrak Station to St. Louis via Chicago Union Station in around 15h 32m.

Operators