The average train between Neu-Isenburg and Milan takes 10h 23m and the fastest train takes 7h 57m. The train service runs several times per day from Neu-Isenburg to Milan. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run every 4 hours between Neu-Isenburg and Milan. The earliest departure is at 5:20 AM in the morning, and the last departure from Neu-Isenburg is at 9:50 PM which arrives into Milan at 11:17 AM. All services require a transfer at Frankfurt, Hauptbahnhof FOB and take an average of 10h 23m. The schedules shown below are for the next available departures.



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8h 47m • 3 changesWant to know about travelling from Neu-Isenburg to Milan? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Neu-Isenburg to Milan. However, there are services departing from Frankfurt station and arriving at Milano Centrale station via Basel SBB station and Lugano station. The journey, including transfers, takes approximately 10h 23m.
Neu-Isenburg to Milan train services, operated by Deutsche Bahn Intercity (DB IC), depart from Frankfurt station.
Neu-Isenburg to Milan train services, operated by Swiss Federal Railways (SBB CFF FFS), arrive at Milano Centrale station.
The distance between Neu-Isenburg and Milan is 511.1 km. The road distance is 655 km.
You can take a vehicle from Frankfurt to Milano Centrale via Frankfurt, Hauptbahnhof FOB, Frankfurt, Basel SBB, and Lugano in around 9h 53m.