The average train between Neu-Isenburg and Berlin takes 4h 36m and the fastest train takes 4h 14m. There is a train service every few hours from Neu-Isenburg to Berlin. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run hourly between Neu-Isenburg and Berlin. The earliest departure is at 12:50 AM at night, and the last departure from Neu-Isenburg is at 7:50 PM which arrives into Berlin at 12:30 AM. All services require a transfer at Frankfurt and take an average of 4h 36m. The schedules shown below are for the next available departures.

4h 14m • 1 change

4h 40m • 1 change

4h 14m • 1 change
Arrives next day

4h 40m • 1 change

7h 16m • 1 change

4h 40m • 1 change

4h 14m • 1 change

4h 21m • 1 change

7h 16m • 1 change

4h 40m • 1 change

4h 14m • 1 change

4h 21m • 1 change

7h 16m • 1 change

4h 40m • 1 change

4h 34m • 1 change

4h 41m • 1 change
Want to know about travelling from Neu-Isenburg to Berlin? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Neu-Isenburg to Berlin. However, there are services departing from Neu-Isenburg station and arriving at Berlin station via Berlin Hbf. The journey, including transfers, takes approximately 4h 36m.
Neu-Isenburg to Berlin train services, operated by Verkehrsgesellschaft Frankfurt (VGF-FFM), depart from Frankfurt station.
Neu-Isenburg to Berlin train services, operated by Verkehrsgesellschaft Frankfurt (VGF-FFM), arrive at Berlin Hbf station.
The distance between Neu-Isenburg and Berlin is 428.1 km. The road distance is 546 km.
Deutsche Bahn Intercity (DB IC) operates a train from Frankfurt to Berlin Hbf hourly. Tickets cost €100–240 and the journey takes 4h 15m.