The average train between Mainz and Southampton takes 9h 20m and the fastest train takes 7h 34m. The train service runs several times per day from Mainz to Southampton. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run every 4 hours between Mainz and Southampton. The earliest departure is at 6:14 AM in the morning, and the last departure from Mainz is at 7:35 PM which arrives into Southampton at 12:00 PM. All services require a transfer at Frankfurt and take an average of 9h 20m. The schedules shown below are for the next available departures.




8h 46m • 4 changes



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8h 35m • 4 changes



8h 34m • 4 changes



8h 37m • 4 changes



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8h 35m • 4 changes



8h 34m • 4 changes



8h 37m • 4 changes



7h 35m • 4 changes



8h 35m • 4 changes



8h 34m • 4 changes



8h 37m • 4 changes



7h 35m • 4 changes



8h 35m • 4 changes



8h 34m • 4 changes



8h 37m • 4 changes



7h 35m • 4 changes



9h 7m • 4 changes



8h 34m • 4 changes



8h 37m • 4 changes



7h 35m • 4 changesWant to know about travelling from Mainz to Southampton? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Mainz to Southampton. However, there are services departing from Frankfurt station and arriving at Southampton Central station via Bruxelles Midi station and London St Pancras Intl station. The journey, including transfers, takes approximately 9h 20m.
Mainz to Southampton train services, operated by Deutsche Bahn Intercity (DB IC), depart from Frankfurt station.
Mainz to Southampton train services, operated by South Western Railway, arrive at Southampton Central station.
Book your Mainz to Southampton train tickets online with Omio.
The distance between Mainz and Southampton is 692.8 km.
You can take a train from Mainz, Römisches Theater to Southampton Central via Frankfurt, Bruxelles Midi, Brussel-Zuid / Bruxelles-Midi, London St Pancras Intl, Euston station, Waterloo Station, and London Waterloo in around 9h 14m.