The average train between Mainz and Neuss takes 2h 59m and the fastest train takes 2h 31m. The train service runs several times per day from Mainz to Neuss. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run every 3 hours between Mainz and Neuss. The earliest departure is at 12:01 AM at night, and the last departure from Mainz is at 10:38 PM which arrives into Neuss at 1:09 AM. All services require a transfer, and take on average 2h 59m. The schedules shown below are for the next available departures.

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2h 47m • 1 changeWant to know about travelling from Mainz to Neuss? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Mainz to Neuss. However, there are services departing from Mainz Hbf station and arriving at Koeln Hbf station via Koeln Hbf station. The journey, including transfers, takes approximately 2h 59m.
Mainz to Neuss train services, operated by Deutsche Bahn Intercity (DB IC), depart from Mainz Hbf station.
Mainz to Neuss train services, operated by Deutsche Bahn Intercity (DB IC), arrive at Koeln Hbf station.
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The distance between Mainz and Neuss is 175.7 km. The road distance is 214 km.
Deutsche Bahn Intercity (DB IC) operates a train from Mainz Hbf to Koeln Hbf hourly. Tickets cost €29–60 and the journey takes 1h 47m. Nederlandse Spoorwegen (NS) also services this route once a week.