The average train between Mainz and Milan takes 10h 2m and the fastest train takes 7h 39m. The train service runs several times per day from Mainz to Milan. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run every 4 hours between Mainz and Milan. The earliest departure is at 1:38 AM at night, and the last departure from Mainz is at 11:08 PM which arrives into Milan at 11:17 AM. All services require a transfer at Mannheim, Hauptbahnhof and take an average of 10h 2m. The schedules shown below are for the next available departures.



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11h 34m • 3 changes



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8h 31m • 3 changes
Want to know about travelling from Mainz to Milan? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Mainz to Milan. However, there are services departing from Mainz station and arriving at Milan station via Mannheim, Hauptbahnhof. The journey, including transfers, takes approximately 10h 2m.
Mainz to Milan train services, operated by Deutsche Bahn Regio (DB Regional), depart from Mainz, Hauptbahnhof station.
Mainz to Milan train services, operated by Deutsche Bahn Regio (DB Regional), arrive at Milano Centrale station.
Book your Mainz to Milan train tickets online with Deutsche Bahn Regio (DB Regional), Deutsche Bahn Intercity (DB IC) and 4 other operators.
The distance between Mainz and Milan is 507.2 km. The road distance is 651 km.
You can take a train from Mainz, Hauptbahnhof to Milano Centrale via Mannheim, Hauptbahnhof, Basel SBB, and Lugano in around 9h 13m.