The average train between Mainz and Milan takes 9h 39m and the fastest train takes 7h 31m. The train service runs several times per day from Mainz to Milan. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run 5 times a day between Mainz and Milan. The earliest departure is at 5:40 AM in the morning, and the last departure from Mainz is at 11:08 PM which arrives into Milan at 11:17 AM. All services require a transfer at Mannheim, Hauptbahnhof and take an average of 9h 39m. The schedules shown below are for the next available departures.



7h 37m • 3 changes



7h 31m • 3 changes



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7h 37m • 3 changes



7h 31m • 3 changes



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8h • 3 changes



7h 37m • 3 changes



7h 31m • 3 changes



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8h • 3 changes
Want to know about travelling from Mainz to Milan? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Mainz to Milan. However, there are services departing from Mainz station and arriving at Milan station via Mannheim, Hauptbahnhof. The journey, including transfers, takes approximately 9h 39m.
Mainz to Milan train services, operated by Deutsche Bahn Intercity (DB IC), depart from Mainz, Hauptbahnhof station.
Mainz to Milan train services, operated by Deutsche Bahn Intercity (DB IC), arrive at Milano Centrale station.
Book your Mainz to Milan train tickets online with Deutsche Bahn Intercity (DB IC), Swiss Federal Railways (SBB CFF FFS) and 3 other operators.
The distance between Mainz and Milan is 507.2 km. The road distance is 652 km.
You can take a train from Mainz, Hauptbahnhof to Milano Centrale via Mannheim, Hauptbahnhof, Basel SBB, and Lugano in around 9h 14m.