The average train between Mainz and Heilbronn takes 2h 26m and the fastest train takes 2h 3m. There is a train service every few hours from Mainz to Heilbronn. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run hourly between Mainz and Heilbronn. The earliest departure is at 5:40 AM in the morning, and the last departure from Mainz is at 9:17 PM which arrives into Heilbronn at 11:59 PM. All services require a transfer, and take on average 2h 26m. The schedules shown below are for the next available departures.

2h 9m • 1 change

2h 32m • 1 change

2h 9m • 1 change

2h 36m • 1 change

2h 9m • 1 change

2h 53m • 1 change

2h 9m • 1 change

2h 36m • 1 change

2h 13m • 1 change

3h 1m • 1 change

2h 3m • 1 change

2h 9m • 1 change

2h 13m • 1 change

3h 1m • 1 change

2h 3m • 1 change

2h 9m • 1 change
Want to know about travelling from Mainz to Heilbronn? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Mainz to Heilbronn. However, there are services departing from Mainz station and arriving at Heilbronn station via Mannheim, Hauptbahnhof. The journey, including transfers, takes approximately 2h 26m.
Mainz to Heilbronn train services, operated by Deutsche Bahn Intercity (DB IC), depart from Mainz, Hauptbahnhof station.
Mainz to Heilbronn train services, operated by Deutsche Bahn Intercity (DB IC), arrive at Heilbronn Hauptbahnhof station.
Book your Mainz to Heilbronn train tickets online with Deutsche Bahn Intercity (DB IC), DB Regio Stuttgart and 2 other operators.
The distance between Mainz and Heilbronn is 115.9 km. The road distance is 156 km.
You can take a train from Mainz, Hauptbahnhof to Heilbronn Hauptbahnhof via Mannheim, Hauptbahnhof in around 2h 33m.