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How to get fromMainz to Lyonby train (TGV), train, bus, car, or plane

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There are 7 ways to get from Mainz to Lyon by train (TGV), train, bus, car, or plane

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Train

    best
    1. Take the train from Mainz, Hauptbahnhof to Mannheim, Hauptbahnhoftrain train 55 / ...
    2. Take the train from Mannheim, Hauptbahnhof to Strasbourg Bahnhoftrain train 82 / ...
    3. Take the train from Strasbourg to Lyon Part Dieutrain train Tgv
    7h 25m
    €119–272

  2. Train, bus

    cheapest
    1. Take the train from Mainz, Römisches Theater to Mannheim, Hauptbahnhoftrain train S5 / ...
    2. Take the bus from Mannheim - Bus Station to Lyon - Gerland Bus Stationbus bus BlaBlaCar Bus
    11h 20m
    €54–145

  3. Drive  652.8 km

    1. Drive from Mainz to Lyoncar car 652.8 km
    6h 2m
    €104–150

  4. Fly Frankfurt to Lyon–Saint Exupéry Airport

    1. Fly from Frankfurt (FRA) to Lyon–Saint Exupéry Airport (LYS)plane plane FRA - LYS
    4h 29m
    €132–311

  5. Bus

    1. Take the bus from FRANKFURT AM MAIN, Hbf Südseite - Pforzheimer Str. to LYON, Lyon - Perrache - poziom górny Abus bus
    11h 55m
    €83–135

  6. Fly Frankfurt to Geneva International Airport, train

    1. Fly from Frankfurt (FRA) to Geneva International Airport (GVA)plane plane FRA - GVA
    2. Take the train from Geneve to Lyon Part Dieutrain train
    6h 42m
    €147–333

  7. Train, train to Strasbourg International Airport, fly to Lyon–Saint Exupéry Airport

    1. Take the train from Mainz, Hauptbahnhof to Mannheim, Hauptbahnhoftrain train
    2. Take the train from Mannheim, Hauptbahnhof to Strasbourg Bahnhoftrain train
    3. Fly from Strasbourg International Airport (SXB) to Lyon–Saint Exupéry Airport (LYS)plane plane SXB - LYS
    6h 1m
    €151–421

Mainz to Lyon by train

Calendar28Weekly Trains
Duration7h 25mAverage Duration
Ticket€119Cheapest Price
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Comparing Your Travel Options

Map of how to get from Mainz to Lyon.ExpandLaunch map view
  • Distance: 710.4 km
  • Duration: 7h 25m

What companies run services between Mainz, Germany and Lyon, France?

You can take a train from Mainz, Hauptbahnhof to Lyon Part Dieu via Mannheim, Hauptbahnhof, Strasbourg Bahnhof, and Strasbourg in around 7h 25m. Alternatively, Lufthansa, Air Dolomiti, and two other airlines fly from Frankfurt (FRA) to Lyon–Saint Exupéry Airport (LYS) every 4 hours.

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