The average train between Macclesfield and Holyhead takes 3h 56m and the fastest train takes 3h 33m. There is a train service every few hours from Macclesfield to Holyhead. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run hourly between Macclesfield and Holyhead. The earliest departure is at 12:14 AM at night, and the last departure from Macclesfield is at 10:06 PM which arrives into Holyhead at 1:49 AM. All services require a transfer, and take on average 3h 56m. The schedules shown below are for the next available departures.

3h 34m • 1 change

3h 37m • 1 change

3h 34m • 1 change

3h 42m • 1 change

8h 36m • 1 change

3h 40m • 1 change

3h 33m • 1 change

3h 34m • 1 change

8h 36m • 1 change

3h 40m • 1 change

3h 33m • 1 change

3h 34m • 1 change

8h 36m • 1 change

3h 40m • 1 change

3h 33m • 1 change

3h 34m • 1 change
Want to know about travelling from Macclesfield to Holyhead? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Macclesfield to Holyhead. However, there are services departing from Macclesfield station and arriving at Holyhead station via Holyhead. The journey, including transfers, takes approximately 3h 56m.
Macclesfield to Holyhead train services, operated by Cross Country, depart from Manchester Piccadilly station.
Macclesfield to Holyhead train services, operated by Cross Country, arrive at Holyhead station.
Book your Macclesfield to Holyhead train tickets online with Cross Country, Transport for Wales and Avanti West Coast.
The distance between Macclesfield and Holyhead is 166.8 km. The road distance is 228 km.
Transport for Wales operates a train from Manchester Piccadilly to Holyhead hourly. Tickets cost £50–85 and the journey takes 2h 56m.