The average train between Grantham and Holyhead takes 6h 19m and the fastest train takes 5h 42m. The train service runs several times per day from Grantham to Holyhead. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run 3 times a day between Grantham and Holyhead. The earliest departure is at 3:00 PM in the afternoon, and the last departure from Grantham is at 7:00 PM which arrives into Holyhead at 2:31 AM. All services require a transfer, and take on average 6h 19m. The schedules shown below are for the next available departures.

5h 42m • 1 change

5h 49m • 1 change
Arrives next day

7h 31m • 1 change

5h 42m • 1 change

5h 49m • 1 change
Arrives next day

7h 33m • 1 change
Want to know about travelling from Grantham to Holyhead? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Grantham to Holyhead. However, there are services departing from Grantham station and arriving at Holyhead station via Manchester Piccadilly. The journey, including transfers, takes approximately 6h 19m.
Grantham to Holyhead train services, operated by East Midlands Railways, depart from Grantham station.
Grantham to Holyhead train services, operated by East Midlands Railways, arrive at Holyhead station.
Book your Grantham to Holyhead train tickets online with East Midlands Railways and Transport for Wales.
The distance between Grantham and Holyhead is 270 km. The road distance is 369 km.
You can take a train from Grantham to Holyhead via Manchester Piccadilly in around 6h 25m.