The average train between Isleworth and Holyhead takes 5h 14m and the fastest train takes 4h 40m. The train service runs several times per day from Isleworth to Holyhead. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run 5 times a day between Isleworth and Holyhead. The earliest departure is at 7:02 AM in the morning, and the last departure from Isleworth is at 11:08 PM which arrives into Holyhead at 11:48 AM. All services require a transfer at Vauxhall and take an average of 5h 14m. The schedules shown below are for the next available departures.


5h 2m • 2 changes


4h 59m • 2 changes


5h 1m • 2 changes


4h 58m • 2 changes


5h 16m • 2 changes


4h 41m • 2 changes


4h 40m • 2 changes
Arrives next day


12h 40m • 2 changes


4h 45m • 2 changes


5h 4m • 2 changes


4h 59m • 2 changes


5h 5m • 2 changes


4h 45m • 2 changes


5h 4m • 2 changes


4h 59m • 2 changes


5h 5m • 2 changes


4h 45m • 2 changes


5h 4m • 2 changes


4h 59m • 2 changes


5h 5m • 2 changes


4h 45m • 2 changes


5h 4m • 2 changes


4h 59m • 2 changes


5h 5m • 2 changes
Want to know about travelling from Isleworth to Holyhead? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Isleworth to Holyhead. However, there are services departing from Isleworth station and arriving at Holyhead station via Holyhead. The journey, including transfers, takes approximately 5h 14m.
Isleworth to Holyhead train services, operated by South Western Railway, depart from London Euston station.
Isleworth to Holyhead train services, operated by South Western Railway, arrive at Holyhead station.
Book your Isleworth to Holyhead train tickets online with South Western Railway, London Underground (Tube) and Avanti West Coast.
The distance between Isleworth and Holyhead is 355.5 km. The road distance is 445 km.
Avanti West Coast operates a train from London Euston to Holyhead 5 times a day. Tickets cost £90–160 and the journey takes 3h 52m.