The average train between Cheltenham Spa and Holyhead takes 4h 23m and the fastest train takes 4h 8m. The train service runs several times per day from Cheltenham Spa to Holyhead. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run 5 times a day between Cheltenham Spa and Holyhead. The earliest departure is at 7:40 AM in the morning, and the last departure from Cheltenham Spa is at 6:40 PM which arrives into Holyhead at 10:48 PM. All services require a transfer, and take on average 4h 23m. The schedules shown below are for the next available departures.

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Want to know about travelling from Cheltenham Spa to Holyhead? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Cheltenham Spa to Holyhead. However, there are services departing from Cheltenham Spa station and arriving at Holyhead station via Stafford. The journey, including transfers, takes approximately 4h 23m.
Cheltenham Spa to Holyhead train services, operated by Cross Country, depart from Cheltenham Spa station.
Cheltenham Spa to Holyhead train services, operated by Cross Country, arrive at Holyhead station.
Book your Cheltenham Spa to Holyhead train tickets online with Cross Country and Avanti West Coast.
The distance between Cheltenham Spa and Holyhead is 232.3 km. The road distance is 326 km.
You can take a train from Cheltenham Spa to Holyhead via Stafford in around 4h 48m.