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How to get fromIsernia to Sienaby train, bus, train (Trenitalia), car, or plane

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There are 7 ways to get from Isernia to Siena by train, bus, train (Trenitalia), car, or plane

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Train, bus

    best
    1. Take the train from Isernia to Cassinotrain train Re
    2. Take the bus from Cassino to Siena, Stazione FSbus bus
    5h 22m
    €29–45

  2. Bus

    cheapest
    1. Take the bus from Isernia to Roma, Autostazione Tiburtinabus bus Campobasso / ...
    2. Take the bus from Roma, Autostazione Tiburtina to Sienabus bus 1550 / ...
    5h 49m
    €25–59

  3. Train (Trenitalia)

    1. Take the train from Isernia to Roma Terminitrain train Re
    2. Take the train from Roma Termini to Firenze S.M.N.train train Fr
    3. Take the train from Firenze S.M.N. to Sienatrain train Re
    6h 8m
    €62–137

  4. Drive 388.1 km

    1. Drive from Isernia to Sienacar car 388.1 km
    3h 57m
    €61–87

  5. Train to Fiumicino International Airport, fly, train

    1. Take the train from Isernia to Roma Terminitrain train
    2. Fly from Fiumicino International Airport (FCO) to Florence Peretola Airport (FLR)plane plane FCO - FLR
    3. Take the train from Firenze S.M.N. to Sienatrain train
    7h 14m
    €100–256

  6. Train via Chiusi (Trenitalia)

    1. Take the train from Isernia to Roma Terminitrain train Re
    2. Take the train from Roma Termini to Chiusi-Chianciano T.train train
    3. Take the train from Chiusi-Chianciano T. to Sienatrain train Re
    6h 48m
    €50–91

  7. Train to Naples Airport, fly, train

    1. Take the train from Isernia to Casertatrain train
    2. Fly from Naples Airport (NAP) to Florence Peretola Airport (FLR)plane plane NAP - FLR
    3. Take the train from Firenze S.M.N. to Sienatrain train
    8h 52m
    €111–243

Isernia to Siena by train, foot, and bus

Calendar7Weekly Services
Duration5h 22mAverage Duration
Ticket€29Cheapest Price
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Questions & Answers

Map of how to get from Isernia to Siena.ExpandLaunch map view
  • Distance: 392.6 km
  • Duration: 5h 22m

What companies run services between Isernia, Italy and Siena, Italy?

You can take a train from Isernia to Siena via Roma Termini and Firenze S.M.N. in around 6h 8m. Alternatively, you can take a bus from Isernia to Siena via Roma, Autostazione Tiburtina in around 5h 49m.

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