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How to get fromIsernia to Sienaby train, bus, car, plane or train (Trenitalia)

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There are 6 ways to get from Isernia to Siena by train, bus, car, plane, or train (Trenitalia)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Train, bus

    best
    1. Take the train from Isernia to Cassinotrain train Re
    2. Take the bus from Cassino to Siena, Stazione FSbus bus
    5h 16m
    €7–9

  2. Train

    1. Take the train from Isernia to Roma Terminitrain train Re
    2. Take the train from Roma Termini to Florence Santa Maria Novellatrain train
    3. Take the train from Firenze S.M.N. to Sienatrain train Re
    6h 41m
    €68–128

  3. Drive 388.1 km

    1. Drive from Isernia to Sienacar car 388.1 km
    3h 54m
    €60–87

  4. Train, fly

    1. Take the train from Isernia to Napoli Centraletrain train
    2. Fly from Naples Airport (NAP) to Florence Peretola Airport (FLR)plane plane NAP - FLR
    3. Take the train from Firenze S.M.N. to Sienatrain train
    8h 58m
    €108–259

  5. Bus

    1. Take the bus from Isernia to Roma, Autostazione Tiburtinabus bus Campobasso / ...
    2. Take the bus from Roma, Autostazione Tiburtina to Sienabus bus 1550 / ...
    5h 33m
    €16–75

  6. Train via Chiusi

    1. Take the train from Isernia to Roma Terminitrain train Re
    2. Take the train from Roma Termini to Chiusi-Chianciano T.train train
    3. Take the train from Chiusi-Chianciano T. to Sienatrain train Re
    7h 36m
    €54–89

Isernia to Siena by train, foot, and bus

Calendar7Weekly Services
Duration5h 16mAverage Duration
Ticket€7Cheapest Price
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Questions & Answers

What companies run services between Isernia, Italy and Siena, Italy?

You can take a train from Isernia to Siena via Roma Termini and Firenze S.M.N. in around 6h 41m. Alternatively, you can take a bus from Isernia to Siena via Roma, Autostazione Tiburtina in around 5h 33m.

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