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How to get fromIsernia to Sienaby train, bus, car, plane or train (Trenitalia)

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There are 6 ways to get from Isernia to Siena by train, bus, car, plane, or train (Trenitalia)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Train, bus

    best
    1. Take the train from Isernia to CassinotrainRe
    2. Take the bus from Cassino to Siena, Stazione FSbus
    5h 20m
    €7–11

  2. Train

    1. Take the train from Isernia to Roma TerminitrainRe
    2. Take the train from Roma Termini to Florence Santa Maria Novellatrain
    3. Take the train from Firenze S.M.N. to SienatrainRe
    6h 45m
    €39–117

  3. Drive 388.1 km

    1. Drive from Isernia to Sienacar388.1 km
    3h 54m
    €61–88

  4. Train, fly

    1. Take the train from Isernia to Napoli Centraletrain
    2. Fly from Naples Airport (NAP) to Florence Peretola Airport (FLR)planeNAP - FLR
    3. Take the train from Firenze S.M.N. to Sienatrain
    8h 57m
    €106–308

  5. Bus

    1. Take the bus from Isernia to Roma, Autostazione TiburtinabusCampobasso / ...
    2. Take the bus from Roma, Autostazione Tiburtina to Sienabus1520 / ...
    5h 43m
    €14–77

  6. Train via Chiusi

    1. Take the train from Isernia to Roma TerminitrainRe
    2. Take the train from Roma Termini to Chiusi-Chianciano T.trainRe
    3. Take the train from Chiusi-Chianciano T. to SienatrainRe
    7h 37m
    €26–79

Isernia to Siena by train, foot, and bus

Calendar7Weekly Services
Duration5h 20mAverage Duration
Ticket€7Cheapest Price
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Questions & Answers

What companies run services between Isernia, Italy and Siena, Italy?

You can take a train from Isernia to Siena via Roma Termini and Firenze S.M.N. in around 6h 45m. Alternatively, you can take a bus from Isernia to Siena via Roma, Autostazione Tiburtina in around 5h 43m.

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