The average train between Hesse and Prague takes 8h 38m and the fastest train takes 7h 25m. The train service runs several times per day from Hesse to Prague. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run every 4 hours between Hesse and Prague. The earliest departure is at 4:41 AM at night, and the last departure from Hesse is at 10:11 PM which arrives into Prague at 10:21 AM. All services require a transfer at Frankfurt and take an average of 8h 38m. The schedules shown below are for the next available departures.



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7h 32m • 3 changesWant to know about travelling from Hesse to Prague? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Hesse to Prague. However, there are services departing from Hesse station and arriving at Prague station via Nürnberg Hbf. The journey, including transfers, takes approximately 8h 38m.
Hesse to Prague train services, operated by Deutsche Bahn Regio (DB Regional), depart from Frankfurt station.
Hesse to Prague train services, operated by Deutsche Bahn Regio (DB Regional), arrive at Praha Hlavni Nadrazi station.
The distance between Hesse and Prague is 386.9 km. The road distance is 567 km.
You can take a train from Frankfurt Konstablerwache to Praha Hlavni Nadrazi via Frankfurt, Nürnberg Hbf, and Schwandorf in around 8h 42m.