The average train between Heilbronn and Mainz takes 3h 2m and the fastest train takes 2h 41m. There is a train service every few hours from Heilbronn to Mainz. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run hourly between Heilbronn and Mainz. The earliest departure is at 4:55 AM at night, and the last departure from Heilbronn is at 10:06 PM which arrives into Mainz at 5:29 AM. All services require a transfer, and take on average 3h 2m. The schedules shown below are for the next available departures.

3h 7m • 1 change

2h 56m • 1 change

2h 56m • 1 change

2h 56m • 1 change

3h 7m • 1 change

2h 56m • 1 change

2h 56m • 1 change

2h 56m • 1 change

3h 7m • 1 change

2h 45m • 1 change

3h 2m • 1 change

2h 56m • 1 change
Want to know about travelling from Heilbronn to Mainz? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Heilbronn to Mainz. However, there are services departing from Heilbronn station and arriving at Mainz station via Mannheim, Hauptbahnhof. The journey, including transfers, takes approximately 3h 2m.
Heilbronn to Mainz train services, operated by DB Regio Stuttgart, depart from Heilbronn Hauptbahnhof station.
Heilbronn to Mainz train services, operated by DB Regio Stuttgart, arrive at Mainz, Römisches Theater station.
Book your Heilbronn to Mainz train tickets online with DB Regio Stuttgart and Deutsche Bahn Regio (DB Regional).
The distance between Heilbronn and Mainz is 115.9 km. The road distance is 166 km.
You can take a train from Heilbronn Hauptbahnhof to Mainz, Römisches Theater via Mannheim, Hauptbahnhof in around 2h 56m.