The train between Buffalo and St. Louis takes 31h 42m. The train runs, on average, 6 times per week from Buffalo to St. Louis. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run 6 times a week between Buffalo and St. Louis. The earliest departure is at 12:25 PM in the afternoon, and the last departure from Buffalo is at 12:25 PM which arrives into St. Louis at 7:07 PM. All services require a transfer at Buffalo Depew Station and take an average of 31h 42m. The schedules shown below are for the next available departures.
Want to know about travelling from Buffalo to St. Louis? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Buffalo to St. Louis. However, there are services departing from Buffalo station and arriving at St. Louis station via Chicago Union Station station. The journey, including transfers, takes approximately 31h 42m.
Buffalo to St. Louis train services, operated by Amtrak, depart from Buffalo Depew Station.
Buffalo to St. Louis train services, operated by Amtrak, arrive at St. Louis station.
Book your Buffalo to St. Louis train tickets online with Amtrak.
The distance between Buffalo and St. Louis is 1,063.3 km. The road distance is 1,311 km.
You can take a train from Buffalo to St. Louis via Buffalo Depew Station and Chicago Union Station in around 17h 36m.
