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How to get fromBuffalo to St. Louisby plane, train (Amtrak), bus (Greyhound), car, or bus

Find Transport to St. Louis

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There are 8 ways to get from Buffalo to St. Louis by plane, train (Amtrak), bus (Greyhound), car, or bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Buffalo Niagara International Airport

    best
    1. Fly from Buffalo Niagara International Airport (BUF) to Lambert–St. Louis International Airport (STL)plane plane BUF - STL
    6h 4m
    $105–555

  2. Train (Amtrak)

    1. Take the train from Buffalo Depew Station to Chicago Union Stationtrain train Lake Shore Limited
    2. Take the train from Chicago Union Station to St. Louistrain train Lincoln Service / ...
    17h 36m
    $442–823

  3. Bus via Akron

    1. Take the bus from Buffalo to Akronbus bus
    2. Take the bus from Akron to Cambridgebus bus
    3. Take the bus from Cambridge, OH to St Louis Bus Stationbus bus
    18h 5m
    $115–236

  4. Drive  737.1 mi

    1. Drive from Buffalo to St. Louiscar car 737.1 mi
    12h 34m
    $135–195

  5. Bus to Rochester, fly

    1. Take the bus from Buffalo to Rochester Bus Stopbus bus
    2. Fly from Rochester (ROC) to Lambert–St. Louis International Airport (STL)plane plane ROC - STL
    7h 22m
    $173–845

  6. Bus to Toronto Pearson International Airport, fly

    1. Take the bus from Buffalo to Mississaugabus bus
    2. Fly from Toronto Pearson International Airport (YYZ) to Lambert–St. Louis International Airport (STL)plane plane YYZ - STL
    7h 51m
    $110–522

  7. Bus to Cleveland-Hopkins International Airport, fly

    1. Take the bus from Buffalo to Cleveland Bus Stationbus bus
    2. Fly from Cleveland-Hopkins International Airport (CLE) to Lambert–St. Louis International Airport (STL)plane plane CLE - STL
    6h 52m
    $531–958

  8. Bus

    1. Take the bus from Buffalo, Ny to Pittsburgh, Pabus bus 530
    2. Take the bus from Pittsburgh Intermodal Station to St Louis Bus Stationbus bus Greyhound US0421
    21h 25m
    $151–373

Buffalo to St. Louis by train (Amtrak)

Calendar14Weekly Trains
Duration17h 36mAverage Duration
Ticket$442Cheapest Price
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Comparing Your Travel Options

Map of how to get from Buffalo to St. Louis.ExpandLaunch map view
  • Distance: 699.1 mi
  • Duration: 6h 4m

What companies run services between Buffalo, NY, USA and St. Louis, MO, USA?

Southwest Airlines, United Airlines, and two other airlines fly from Buffalo Niagara International Airport (BUF) to Lambert–St. Louis International Airport (STL) hourly. Alternatively, you can take a train from Buffalo to St. Louis via Buffalo Depew Station and Chicago Union Station in around 17h 36m.

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