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How to get fromBuffalo to St. Louisby plane, train (Amtrak), bus (Greyhound), car, bus or shuttle

Find Transport to St. Louis

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There are 7 ways to get from Buffalo to St. Louis by plane, train (Amtrak), bus (Greyhound), car, bus, or shuttle

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Buffalo Niagara International Airport

    best
    1. Fly from Buffalo Niagara International Airport (BUF) to Lambert–St. Louis International Airport (STL)plane plane BUF - STL
    6h 13m
    $197–1,083

  2. Bus via Akron

    cheapest
    1. Take the bus from Buffalo, NY to Akron, OHbus bus
    2. Take the bus from Akron to Cambridgebus bus
    3. Take the bus from Cambridge, OH to St Louis Bus Stationbus bus
    18h 20m
    $85–226

  3. Train (Amtrak)

    1. Take the train from Buffalo Depew Station to Chicago Union Stationtrain train Lake Shore Limited
    2. Take the train from Chicago Union Station to St. Louistrain train Lincoln Service / ...
    17h 36m
    $114–494

  4. Drive 736.9 mi

    1. Drive from Buffalo to St. Louiscar car 736.9 mi
    12h 24m
    $135–195

  5. Bus to Rochester, fly

    1. Take the bus from Buffalo, NY to Rochester, NYbus bus
    2. Fly from Rochester (ROC) to Lambert–St. Louis International Airport (STL)plane plane ROC - STL
    8h 28m
    $177–988

  6. Shuttle to Toronto Pearson International Airport, fly

    1. Take a shuttle bus from Buffalo Airport to Pearson International Airport Terminal 1shuttle bus
    2. Fly from Toronto Pearson International Airport (YYZ) to Lambert–St. Louis International Airport (STL)plane plane YYZ - STL
    7h 57m
    $347–953

  7. Bus

    1. Take the bus from Buffalo to Pittsburghbus bus Fab530
    2. Take the bus from Pittsburgh Intermodal Station to St Louis Bus Stationbus bus Greyhound US0421
    21h 25m
    $109–355

Buffalo to St. Louis by train (Amtrak)

Calendar14Weekly Trains
Duration17h 36mAverage Duration
Ticket$114Cheapest Price
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Questions & Answers

What companies run services between Buffalo, NY, USA and St. Louis, MO, USA?

Southwest Airlines, Delta, and two other airlines fly from Buffalo Niagara International Airport (BUF) to Lambert–St. Louis International Airport (STL) every 3 hours. Alternatively, you can take a train from Buffalo to St. Louis via Buffalo Depew Station and Chicago Union Station in around 17h 36m.

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