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There are 7 ways to get from Buffalo to St Louis by plane, bus, shuttle, train or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2rio's travel planner.

Recommended option

Fly from Buffalo  •  5h 50m

  1. Fly from Buffalo (BUF) to St. Louis (STL) BUF - STL

$95 - $335

Cheapest option

Bus  •  23h 7m

  1. Take the bus from Buffalo to Toronto
  2. Take the bus from Toronto, ON - 610 Bay Street to Chicago, IL - 630 West Harrison Street
  3. Take the bus from Chicago, IL to St. Louis

$77 - $153

5 alternative options

Bus to Rochester, fly  •  8h 20m

  1. Take the bus from Buffalo, Ny to Rochester, Ny
  2. Fly from Rochester (ROC) to St. Louis (STL) ROC - STL

$94 - $409

Shuttle to Toronto, fly  •  8h 36m

  1. Take a shuttle bus from Buffalo Airport to Toronto Airport (YYZ)
  2. Fly from Toronto (YYZ) to St. Louis (STL) YYZ - STL

$195 - $375

Bus via Columbus  •  17h 25m

  1. Take the bus from Buffalo, NY to Columbus, OH Buffalo
  2. Take the bus from Columbus, Oh to Greyhound Bus Station St. Louis 1683 / ...

$91 - $149

Train  •  18h 16m

  1. Take the train from Buffalo Depew Station to Chicago Union Station Lake Shore Limited
  2. Take the train from Chicago Union Station to St. Louis Gateway Station Lincoln Service / ...

$121 - $179

Drive  •  12h 30m

  1. Drive from Buffalo to St Louis 746.3 miles

$70 - $110

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Last updated: July 31 | Data sourced from: ACAPS, OXFORD

Questions & Answers

The cheapest way to get from Buffalo to St Louis is to drive which costs $70 - $110 and takes 12h 30m.

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The quickest way to get from Buffalo to St Louis is to fly which costs $95 - $340 and takes 5h 50m.

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No, there is no direct bus from Buffalo to St Louis station. However, there are services departing from Buffalo, NY and arriving at Greyhound Bus Station St. Louis via Columbus, Oh. The journey, including transfers, takes approximately 17h 25m.

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No, there is no direct train from Buffalo station to St Louis station. However, there are services departing from Buffalo Amtrak Station and arriving at St. Louis Gateway Station via Buffalo Depew Station and Chicago Union Station. The journey, including transfers, takes approximately 18h 16m.

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The distance between Buffalo and St Louis is 665 miles. The road distance is 746.3 miles.

Get driving directions

The best way to get from Buffalo to St Louis without a car is to bus via Columbus which takes 17h 25m and costs $90 - $150.

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It takes approximately 5h 50m to get from Buffalo to St Louis, including transfers.

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Buffalo to St Louis bus services, operated by Barons Bus, depart from Buffalo, NY station.

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Buffalo to St Louis train services, operated by Amtrak, depart from Buffalo Depew Station.

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The best way to get from Buffalo to St Louis is to fly which takes 5h 50m and costs $95 - $340. Alternatively, you can bus via Columbus, which costs $90 - $150 and takes 17h 25m, you could also train, which costs $120 - $180 and takes 18h 16m.

Mode details

Map of how to get from Buffalo to St Louis.
Launch map view
  • Distance: 664.6 miles
  • Duration: 5h 50m

What companies run services between Buffalo, NY, USA and St Louis, MO, USA?

Southwest Airlines, American Airlines and two other airlines fly from Buffalo to St Louis hourly. Alternatively, you can take a bus from Buffalo to St Louis via Columbus, OH and Columbus, Oh in around 17h 25m.

Airlines
American Airlines
Website
aa.com
Flights from Buffalo to St. Louis via Chicago O'Hare
Ave. Duration
4h 13m
When
Every day
Estimated price
$80 - $400
Flights from Buffalo to St. Louis via Reagan Washington
Ave. Duration
4h 48m
When
Every day
Estimated price
$85 - $410
Flights from Buffalo to St. Louis via Charlotte
Ave. Duration
4h 46m
When
Every day
Estimated price
$90 - $410
Flights from Buffalo to St. Louis via Philadelphia
Ave. Duration
4h 58m
When
Every day
Estimated price
$85 - $410
Flights from Rochester to St. Louis via Chicago O'Hare
Ave. Duration
4h 57m
When
Every day
Estimated price
$75 - $380
Flights from Rochester to St. Louis via Charlotte
Ave. Duration
4h 48m
When
Every day
Estimated price
$85 - $380
Flights from Rochester to St. Louis via Philadelphia
Ave. Duration
5h 18m
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$80 - $380
Flights from Rochester to St. Louis via Reagan Washington
Ave. Duration
5h 38m
When
Every day
Estimated price
$80 - $380
Flights from Toronto to St. Louis via Chicago O'Hare
Ave. Duration
4h 15m
When
Every day
Estimated price
$220 - $600
Flights from Toronto to St. Louis via Reagan Washington
Ave. Duration
5h
When
Every day
Estimated price
$220 - $600
United Airlines
Website
united.com
Flights from Buffalo to St. Louis via Chicago O'Hare
Ave. Duration
4h 24m
When
Every day
Estimated price
$95 - $440
Flights from Buffalo to St. Louis via Washington Dulles
Ave. Duration
4h 35m
When
Every day
Estimated price
$100 - $460
Flights from Rochester to St. Louis via Chicago O'Hare
Ave. Duration
4h 45m
When
Every day
Estimated price
$90 - $410
Flights from Rochester to St. Louis via Washington Dulles
Ave. Duration
4h 39m
When
Every day
Estimated price
$100 - $430
Flights from Rochester to St. Louis via Newark
Ave. Duration
5h 46m
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$100 - $450
Flights from Toronto to St. Louis
Ave. Duration
2h 7m
When
Every day
Estimated price
$65 - $300
Flights from Toronto to St. Louis via Chicago O'Hare
Ave. Duration
4h 29m
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$290 - $460
Flights from Toronto to St. Louis via Washington Dulles
Ave. Duration
4h 35m
When
Every day
Estimated price
$290 - $460
Air Canada
Website
aircanada.com
Flights from Buffalo to St. Louis via Chicago O'Hare
Ave. Duration
4h 24m
When
Every day
Estimated price
$95 - $440
Flights from Rochester to St. Louis via Chicago O'Hare
Ave. Duration
4h 45m
When
Every day
Estimated price
$90 - $410
Flights from Toronto to St. Louis
Ave. Duration
2h 7m
When
Every day
Estimated price
$65 - $300
Flights from Toronto to St. Louis via Chicago O'Hare
Ave. Duration
4h 21m
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$290 - $460
Delta
Website
delta.com
Flights from Buffalo to St. Louis via Detroit
Ave. Duration
4h 42m
When
Every day
Estimated price
$420 - $750
Flights from Buffalo to St. Louis via New York La Guardia
Ave. Duration
5h 1m
When
Monday to Saturday
Estimated price
$420 - $950
Flights from Rochester to St. Louis via Detroit
Ave. Duration
4h 52m
When
Every day
Estimated price
$390 - $700
Flights from Rochester to St. Louis via New York La Guardia
Ave. Duration
5h 6m
When
Monday to Friday
Estimated price
$390 - $850
Flights from Rochester to St. Louis via Atlanta
Ave. Duration
5h 10m
When
Every day
Estimated price
$390 - $900
Flights from Toronto to St. Louis via Detroit
Ave. Duration
4h
When
Every day
Estimated price
$440 - $750
Flights from Toronto to St. Louis via Atlanta
Ave. Duration
4h 55m
When
Every day
Estimated price
$440 - $1,000
Southwest Airlines
Website
southwest.com
Flights from Buffalo to St. Louis via Chicago Midway
Ave. Duration
4h 1m
When
Every day
Estimated price
$90 - $330
Flights from Rochester to St. Louis via Baltimore
Ave. Duration
4h 20m
When
Every day
Estimated price
$95 - $330
Train operators
Amtrak

Amtrak is a rail service that connects the US and three Canadian provinces. Covering 21,000 route miles (34,000km) Amtrak operates more than 300 trains daily. These medium and long distance intercity services operate at speeds of up to 240km/h, to more than 500 destinations. Founded in 1971, it is based in Washington, D.C. and offers four classes of travel: First Class, Sleeper, Business and Coach. Ticket fares are divided into five subclasses: Saver, Value, Flexible, Business and Premium. Amtrak trains are known for their wide seats, plug-in power, big windows and storage capabilities.

Rome2rio's guide to Amtrak
Contact Details
Phone
+1 215-856-7924
Website
amtrak.com
Train from Buffalo Depew Station to Chicago Union Station
Ave. Duration
10h 30m
Frequency
Twice daily
Estimated price
$60 - $90
Website
amtrak.com
Coach Seat
$60 - $90
Premium
$250 - $350
Flexi Coach Seat
$120 - $180
Business Seat
$120 - $180
Train from Chicago Union Station to St. Louis Gateway Station
Ave. Duration
5h 30m
Frequency
5 times a day
Estimated price
$40 - $60
Website
amtrak.com
Coach Seat
$40 - $60
Premium
$210 - $300
Flexi Coach Seat
$75 - $110
Business Seat
$75 - $110
Bus operators
Greyhound USA

Greyhound is a leading bus company based in Dallas, Texas, serving over 3800 destinations across North America, Mexico and Canada. Greyhound carries around 18 million passengers a year who travel 5.4 billion miles (8.6 billion km) a year on their fleet of around 1700 vehicles. For travel flexibility, you can board or get off a Greyhound bus at official Greyhound stations, partner stations and curbside stops. There are around 230 Greyhound stations across the US where you can both catch your bus and buy tickets, that are also available on the official website and via the mobile app.

Rome2rio's guide to Greyhound USA
Contact Details
Phone
+1 214-849-8100/1-800-231-2222
Email
ifsr@greyhound.com
Website
greyhound.com
Bus from Buffalo, Ny to Rochester, Ny
Ave. Duration
1h 35m
Frequency
Every 3 hours
Estimated price
$14 - $21
Website
greyhound.com
Economy
$14 - $21
Flexible
$30 - $50
Bus from Columbus, Oh to Greyhound Bus Station St. Louis
Ave. Duration
9h 10m
Frequency
5 times a day
Estimated price
$45 - $65
Website
greyhound.com
Economy
$45 - $65
Flexible
$75 - $110
Greyhound Canada
Phone
+1 1-800-661-8747
Email
Canada.info@greyhound.ca
Website
greyhound.ca
Bus from Buffalo, NY - 181 Ellicott Street to Rochester, NY - 186 Cumberland Street
Ave. Duration
1h 30m
Frequency
3 times a day
Estimated price
$10 - $24
Website
Greyhound.ca
International
$35 - $50
Online Fare
$10 - $15
Advanced Purchase
$16 - $24
Standard Fare
$20 - $24
Refundable
$28 - $30
Bus from Toronto, ON - 610 Bay Street to Chicago, IL - 630 West Harrison Street
Ave. Duration
12h 35m
Frequency
3 times a day
Estimated price
$45 - $85
Website
Greyhound.ca
International
$60 - $85
Online Fare
$45 - $65
Advanced Purchase
$55 - $80
Standard Fare
$75 - $85
Refundable
$85 - $95
Trailways New York
Phone
(800) 858-8555
Website
trailwaysny.com
Bus from Buffalo, NY to Rochester, NY
Ave. Duration
1h 35m
Frequency
Once daily
Estimated price
$18 - $26
Book at
trailwaysny.com
Niagara Airbus
Megabus
Phone
877-462-6342
Website
us.megabus.com
Bus from Buffalo to Toronto
Ave. Duration
2h 25m
Frequency
4 times a week
Estimated price
$9 - $23
Book at
megabus.com
Bus from Chicago, IL to St. Louis
Ave. Duration
6h
Frequency
Twice daily
Estimated price
$23 - $45
Book at
megabus.com

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More Questions & Answers

There is no direct flight from Buffalo Airport to St. Louis Airport. The quickest flight takes 3h 35m and has one stopover.

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Buffalo to St Louis bus services, operated by Greyhound USA, arrive at Greyhound Bus Station St. Louis.

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St Louis is 1h behind Buffalo. It is currently 5:54 AM in Buffalo and 4:54 AM in St Louis.

Buffalo to St Louis train services, operated by Amtrak, arrive at St. Louis Gateway Station.

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Yes, the driving distance between Buffalo to St Louis is 746 miles. It takes approximately 12h 30m to drive from Buffalo to St Louis.

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Southwest Airlines, Delta, United Airlines and American Airlines offer flights from Buffalo Airport to St. Louis Airport.

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Book your Buffalo to St Louis train tickets online with Omio and Omio.

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There are 301+ hotels available in St Louis. Prices start at $100 USD per night.

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The best way to get from Buffalo to Buffalo Airport is to line 24 bus which takes 34 min and costs $2.

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