The average train between Brno and Mainz takes 12h 38m and the fastest train takes 10h 34m. The train service runs several times per day from Brno to Mainz. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run 3 times a day between Brno and Mainz. The earliest departure is at 7:18 AM in the morning, and the last departure from Brno is at 10:18 PM which arrives into Mainz at 2:22 PM. All services require a transfer at Wien Hbf and take an average of 12h 38m. The schedules shown below are for the next available departures.


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10h 34m • 2 changes
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10h 34m • 2 changes
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17h 4m • 2 changes
Want to know about travelling from Brno to Mainz? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Brno to Mainz. However, there are services departing from Brno station and arriving at Mainz station via Wien Hbf. The journey, including transfers, takes approximately 12h 38m.
Brno to Mainz train services, operated by České dráhy (ČD), depart from Brno Hlavni Nadrazi station.
Brno to Mainz train services, operated by České dráhy (ČD), arrive at Frankfurt(Main)Hbf station.
The distance between Brno and Mainz is 606.4 km. The road distance is 917 km.
You can take a train from Brno Hlavni Nadrazi to Mainz, Römisches Theater via Wien Hbf, Frankfurt(Main)Hbf, and Frankfurt in around 9h 44m.