The average train between Avignon and Issoire takes 7h 9m and the fastest train takes 4h 46m. The train service runs several times per day from Avignon to Issoire. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run every 4 hours between Avignon and Issoire. The earliest departure is at 10:22 AM in the morning, and the last departure from Avignon is at 8:49 PM which arrives into Issoire at 10:16 AM. All services require a transfer at Lyon Part Dieu and take an average of 7h 9m. The schedules shown below are for the next available departures.


4h 59m • 2 changes

5h • 2 changes

4h 49m • 2 changes

5h 32m • 2 changes

4h 59m • 2 changes

5h • 2 changes

4h 49m • 2 changes

5h 32m • 2 changes

4h 59m • 2 changes

5h • 2 changes

4h 49m • 2 changes

5h 17m • 2 changes

4h 46m • 2 changes

5h 36m • 2 changes

5h • 2 changesArrives next day


15h 26m • 2 changes

4h 46m • 2 changes

5h 35m • 2 changes

5h • 2 changes

4h 50m • 2 changesWant to know about travelling from Avignon to Issoire? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Avignon to Issoire. However, there are services departing from Avignon station and arriving at Issoire station via Lyon Part Dieu. The journey, including transfers, takes approximately 7h 9m.
Avignon to Issoire train services, operated by TGV inOui, depart from Avignon Tgv station.
Avignon to Issoire train services, operated by TGV inOui, arrive at Clermont Ferrand station.
Book your Avignon to Issoire train tickets online with TGV inOui and Société Nationale des Chemins de fer Français (SNCF).
The distance between Avignon and Issoire is 216 km. The road distance is 480 km.
You can take a train from Avignon Tgv to Issoire via Lyon Part Dieu and Clermont Ferrand in around 5h 34m.