The average train between Avignon and Issoire takes 7h 4m and the fastest train takes 4h 47m. The train service runs several times per day from Avignon to Issoire. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run every 4 hours between Avignon and Issoire. The earliest departure is at 7:41 AM in the morning, and the last departure from Avignon is at 8:49 PM which arrives into Issoire at 10:16 AM. All services require a transfer at Lyon Part Dieu and take an average of 7h 4m. The schedules shown below are for the next available departures.


4h 57m • 2 changes


5h 1m • 2 changes


5h • 2 changes


4h 52m • 2 changes


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5h • 2 changes


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7h 27m • 2 changes


6h 40m • 2 changes


6h 4m • 2 changes
Arrives next day


17h 22m • 2 changes


4h 47m • 2 changes


5h 38m • 2 changes


5h • 2 changes


4h 53m • 2 changes


4h 57m • 2 changes


5h 1m • 2 changes


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4h 52m • 2 changes


4h 57m • 2 changes


5h 1m • 2 changes


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4h 52m • 2 changes
Want to know about travelling from Avignon to Issoire? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Avignon to Issoire. However, there are services departing from Avignon station and arriving at Issoire station via Lyon Part Dieu. The journey, including transfers, takes approximately 7h 4m.
Avignon to Issoire train services, operated by TGV inOui, depart from Avignon Tgv station.
Avignon to Issoire train services, operated by TGV inOui, arrive at Clermont Ferrand station.
Book your Avignon to Issoire train tickets online with TGV inOui, Société Nationale des Chemins de fer Français (SNCF) and Trenitalia.
The distance between Avignon and Issoire is 216 km. The road distance is 480 km.
You can take a train from Avignon Tgv to Issoire via Lyon Part Dieu and Clermont Ferrand in around 5h 44m.