The average bus between Waltham and Hyannis takes 2h 38m and the fastest bus takes 2h 25m. The bus service runs several times per day from Waltham to Hyannis. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run every 4 hours between Waltham and Hyannis. The earliest departure is at 5:50 AM in the morning, and the last departure from Waltham is at 6:50 PM which arrives into Hyannis at 9:15 PM. All services require a transfer at Lincoln St @ Essex St and take an average of 2h 38m. The schedules shown below are for the next available departures.

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Want to know about travelling from Waltham to Hyannis? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Waltham to Hyannis. However, there are services departing from Waltham station and arriving at Hyannis station via Lincoln St @ Essex St. The journey, including transfers, takes approximately 2h 38m.
Waltham to Hyannis bus services, operated by MBTA, depart from Carter St opp Commuter Rail Station.
Waltham to Hyannis bus services, operated by MBTA, arrive at Hyannis Transportation Center station.
The distance between Waltham and Hyannis is 112.5 km. The road distance is 140 km.
You can take a bus from Carter St opp Commuter Rail Station to Hyannis Transportation Center via Lincoln St @ Essex St and Boston South Buses in around 3h 15m.