The average bus between Philadelphia and Hyannis takes 12h 32m and the fastest bus takes 8h 50m. The bus service runs several times per day from Philadelphia to Hyannis. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run 4 times a day between Philadelphia and Hyannis. The earliest departure is at 2:20 AM at night, and the last departure from Philadelphia is at 7:30 PM which arrives into Hyannis at 9:35 AM. All services require a transfer at Boston and take an average of 12h 32m. The schedules shown below are for the next available departures.

10h 20m • 1 change

10h 20m • 1 change
Arrives next day

21h 15m • 1 change

8h 50m • 1 change

10h 20m • 1 change

10h 20m • 1 change
Arrives next day

21h 15m • 1 change

8h 50m • 1 change

10h 20m • 1 change
Arrives next day

21h 15m • 1 change

8h 50m • 1 change

10h 20m • 1 change

10h 20m • 1 change
Arrives next day

14h 5m • 1 change

8h 50m • 1 change

10h 20m • 1 change

10h 20m • 1 change
Arrives next day

21h 15m • 1 change
Want to know about travelling from Philadelphia to Hyannis? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Philadelphia to Hyannis. However, there are services departing from Philadelphia station and arriving at Hyannis station via Boston. The journey, including transfers, takes approximately 12h 32m.
Philadelphia to Hyannis bus services, operated by Greyhound USA, depart from Philadelphia Bus Station.
Philadelphia to Hyannis bus services, operated by Greyhound USA, arrive at Hyannis Transportation Center station.
Book your Philadelphia to Hyannis bus tickets online with Greyhound USA, Peter Pan Bus Lines and Flixbus USA.
The distance between Philadelphia and Hyannis is 452.2 km. The road distance is 663 km.
You can take a bus from Philadelphia Bus Station to Hyannis Transportation Center via Boston and Boston South Station in around 9h 45m.