The average bus between St. Louis and Hyannis takes 33h 55m and the fastest bus takes 33h 50m. The bus service runs several times per day from St. Louis to Hyannis. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run twice daily between St. Louis and Hyannis. The earliest departure is at 2:00 AM at night, and the last departure from St. Louis is at 8:45 AM which arrives into Hyannis at 7:45 PM. All services require a transfer at Port Authority Bus Terminal and take an average of 33h 55m. The schedules shown below are for the next available departures.
Arrives next day


34h 50m • 2 changes
Arrives next day


35h • 2 changes
Arrives next day


34h 50m • 2 changes
Arrives next day


35h • 2 changes
Arrives next day


34h 50m • 2 changes
Arrives next day


35h • 2 changes
Want to know about travelling from St. Louis to Hyannis? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from St. Louis to Hyannis. However, there are services departing from St. Louis station and arriving at Hyannis station via Port Authority Bus Terminal. The journey, including transfers, takes approximately 33h 55m.
St. Louis to Hyannis bus services, operated by Greyhound USA, depart from St Louis Bus Station.
St. Louis to Hyannis bus services, operated by Greyhound USA, arrive at Hyannis Transportation Center station.
The distance between St. Louis and Hyannis is 1,721.9 km. The road distance is 2,105 km.
You can take a bus from St Louis Bus Station to Hyannis Transportation Center via Port Authority Bus Terminal and Providence Bus Terminal in around 32h 35m.