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How to get fromSt. Louis to Hyannisby plane, bus, train, bus (Greyhound), or car

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There are 6 ways to get from St. Louis to Hyannis by plane, bus, train, bus (Greyhound), or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Boston Logan Airport, bus

    best
    1. Fly from Lambert–St. Louis International Airport (STL) to Boston Logan Airport (BOS)plane plane STL - BOS
    2. Take the bus from Logan International Airport to Hyannis Transportation Centerbus bus
    6h 39m
    $390–892

  2. Fly to Barnstable Municipal Airport

    cheapest
    1. Fly from Lambert–St. Louis International Airport (STL) to Barnstable Municipal Airport (HYA)plane plane STL - HYA
    5h 51m
    $142–702

  3. Train, bus

    1. Take the train from St. Louis to Chicago Union Stationtrain train
    2. Take the train from Chicago Union Station to Bostontrain train
    3. Take the bus from Boston South Buses to Hyannis Transportation Centerbus bus
    30h 8m
    $359–794

  4. Bus

    1. Take the bus from St Louis Bus Station to Port Authority Bus Terminalbus bus
    2. Take the bus from New York to Bostonbus bus
    3. Take the bus from Boston South Buses to Hyannis Transportation Centerbus bus
    32h 23m
    $230–367

  5. Drive  1,185.1 mi

    1. Drive from St. Louis to Hyanniscar car 1,185.1 mi
    21h 22m
    $217–313

  6. Fly to Manchester Airport, bus

    1. Fly from Lambert–St. Louis International Airport (STL) to Manchester Airport (MHT)plane plane STL - MHT
    2. Take the bus from Boston Manchester Airport to Bostonbus bus
    3. Take the bus from Boston South Buses to Hyannis Transportation Centerbus bus
    10h 32m
    $158–650

St. Louis to Hyannis by train and bus

Calendar7Weekly Services
Duration30h 8mAverage Duration
Ticket$359Cheapest Price
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Comparing Your Travel Options

Map of how to get from St. Louis to Hyannis.ExpandLaunch map view
  • Distance: 1,134.6 mi
  • Duration: 6h 39m

What companies run services between St. Louis, MO, USA and Hyannis, MA, USA?

You can take a bus from St Louis Bus Station to Hyannis Transportation Center via Port Authority Bus Terminal, New York, Boston, and Boston South Buses in around 32h 23m. Alternatively, Southwest Airlines, Cape Air, and American Airlines fly from Lambert–St. Louis International Airport (STL) to Barnstable Municipal Airport (HYA) 6 times a week.

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