Rome2Rio

Santander to Rome buses

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Trip Overview

The average bus between Santander and Rome takes 46h 48m and the fastest bus takes 46h 35m. The bus runs, on average, 5 times per week from Santander to Rome. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

46h 48m
Duration
1,987 km
Distance
€197
Average price
5 times a week
Frequency

Santander to Rome bus times

Buses run 5 times a week between Santander and Rome. The earliest departure is at 4:50 PM in the afternoon, and the last departure from Santander is at 5:50 PM which arrives into Rome at 5:25 PM. All services require a transfer at Bordeaux and take an average of 46h 48m. The schedules shown below are for the next available departures.

Departing Wednesday, October 21, 2026

  •  → 

    Arrives +2 days

    FlixBusFlixBusFlixBus46h 35m • 2 changes

Departing Thursday, October 22, 2026

  •  → 

    Arrives +2 days

    FlixBusFlixBusFlixBus46h 35m • 2 changes

Departing Friday, October 23, 2026

  •  → 

    Arrives +2 days

    FlixBusFlixBusFlixBus46h 40m • 2 changes

Departing Saturday, October 24, 2026

  •  → 

    Arrives +2 days

    FlixBusFlixBusFlixBus47h 35m • 2 changes

Departing Sunday, October 25, 2026

  •  → 

    Arrives +2 days

    FlixBusFlixBusFlixBus46h 35m • 2 changes

Frequently asked questions

Want to know about travelling from Santander to Rome? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from Santander to Rome.ExpandLaunch map view
  • Distance: 1,987.1 km
  • Duration: 46h 48m

What companies run services between Santander, Spain and Rome, Italy?

You can take a bus from Estación de autobuses de Santander to Roma, Autostazione Tiburtina via Bordeaux and Florence Villa Constanza Bus Station in around 27h 58m.

Operators