Rome2Rio

Santander to Rome buses

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Trip Overview

The bus between Santander and Rome takes 45h 5m. The bus runs, on average, once a week from Santander to Rome. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

45h 5m
Duration
1,987 km
Distance
€211
Average price
Once a week
Frequency

Santander to Rome bus times

Buses run once a week between Santander and Rome. The service departs Santander at 8:20 PM in the evening, which arrives into Rome at 17:25:00. All services require a transfer at Bordeaux and take an average of 45h 5m. The schedules shown below are for the next available departures.

Departing Thursday, November 12, 2026

  •  → 

    Arrives +2 days

    FlixBusFlixBusFlixBus45h 5m • 2 changes

Frequently asked questions

Want to know about travelling from Santander to Rome? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from Santander to Rome.ExpandLaunch map view
  • Distance: 1,987.2 km
  • Duration: 45h 5m

What companies run services between Santander, Spain and Rome, Italy?

You can take a bus from Santander to Roma, Autostazione Tiburtina via Bordeaux and Florence Villa Constanza Bus Station in around 27h 22m.

Operators