The average bus between Rome, Termini and Siena takes 3h 32m and the fastest bus takes 3h 9m. The bus service runs several times per day from Rome, Termini to Siena. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run every 4 hours between Rome, Termini and Siena. The earliest departure is at 5:35 AM in the morning, and the last departure from Rome, Termini is at 9:15 PM which arrives into Siena at 12:40 AM. All services require a transfer, and take on average 3h 32m. The schedules shown below are for the next available departures.

3h 13m • 1 change

3h 26m • 1 change
Arrives next day

3h 31m • 1 change

3h 18m • 1 change

3h 19m • 1 change

3h 41m • 1 change

3h 39m • 1 change

3h 19m • 1 change

3h 28m • 1 change

3h 22m • 1 change

3h 20m • 1 change

3h 19m • 1 change

3h 19m • 1 change

3h 19m • 1 change

3h 20m • 1 change

3h 39m • 1 change

3h 35m • 1 change

3h 20m • 1 change

3h 20m • 1 change
Want to know about travelling from Rome, Termini to Siena? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Rome, Termini to Siena. However, there are services departing from Rome, Termini station and arriving at Siena station via Siena. The journey, including transfers, takes approximately 3h 32m.
Rome, Termini to Siena bus services, operated by ATAC S.p.A. Azienda per la mobilità, depart from Roma, Autostazione Tiburtina station.
Rome, Termini to Siena bus services, operated by ATAC S.p.A. Azienda per la mobilità, arrive at Siena station.
The distance between Rome, Termini and Siena is 184.3 km. The road distance is 237 km.
FlixBus operates a bus from Roma, Autostazione Tiburtina to Siena every 3 hours. Tickets cost €16–27 and the journey takes 2h 39m. AutoLinee Moretti also services this route 3 times a week.