The average bus between Pisa and Messina takes 19h 26m and the fastest bus takes 18h. The bus service runs several times per day from Pisa to Messina. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run twice daily between Pisa and Messina. The earliest departure is at 4:45 AM at night, and the last departure from Pisa is at 10:00 PM which arrives into Messina at 7:50 PM. All services require a transfer, and take on average 19h 26m. The schedules shown below are for the next available departures.
Arrives next day

25h 35m • 1 change
Arrives next day

18h • 1 change
Arrives next day

18h 20m • 1 change
Arrives next day

18h • 1 change
Arrives next day

21h 50m • 1 change
Arrives next day

18h 20m • 1 change
Arrives next day

18h • 1 change
Arrives next day

21h 50m • 1 change
Arrives next day

18h 20m • 1 change
Arrives next day

18h • 1 change
Arrives next day

21h 50m • 1 change
Want to know about travelling from Pisa to Messina? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Pisa to Messina. However, there are services departing from Pisa station and arriving at Messina station via Florence Villa Constanza Bus Station station. The journey, including transfers, takes approximately 19h 26m.
Pisa to Messina bus services, operated by FlixBus, depart from Pisa station.
Pisa to Messina bus services, operated by FlixBus, arrive at Messina station.
Book your Pisa to Messina bus tickets online with FlixBus.
The distance between Pisa and Messina is 750 km. The road distance is 1,021 km.
You can take a bus from Pisa to Messina via Florence Villa Constanza Bus Station in around 14h 20m.