The average bus between Milan and Sistine Chapel takes 10h 50m and the fastest bus takes 9h 49m. The bus service runs several times per day from Milan to Sistine Chapel. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run 3 times a day between Milan and Sistine Chapel. The earliest departure is at 1:10 AM at night, and the last departure from Milan is at 9:20 PM which arrives into Sistine Chapel at 8:40 AM. All services require a transfer at Firenze and take an average of 10h 50m. The schedules shown below are for the next available departures.


11h 4m • 2 changes
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9h 49m • 2 changes
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11h 7m • 2 changes


9h 51m • 2 changes
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9h 53m • 2 changes
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11h 4m • 2 changes


9h 55m • 2 changes
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9h 49m • 2 changes
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11h 20m • 2 changes


9h 58m • 2 changes


10h 57m • 2 changes
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9h 53m • 2 changes
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11h 20m • 2 changes
Want to know about travelling from Milan to Sistine Chapel? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Milan to Sistine Chapel. However, there are services departing from Milan station and arriving at Sistine Chapel station via Florence Villa Constanza Bus Station station. The journey, including transfers, takes approximately 10h 50m.
Milan to Sistine Chapel bus services, operated by FlixBus, depart from Milano, San Donato M3 station.
Milan to Sistine Chapel bus services, operated by FlixBus, arrive at Roma station.
The distance between Milan and Sistine Chapel is 475 km. The road distance is 575 km.
You can take a bus from Milano, San Donato M3 to Sistine Chapel via Firenze, Roma, Lorenzo Il Magnifico/Pulci, and Cavalleggeri/S. Pietro in around 7h 57m.