Rome2Rio

Milan to Sistine Chapel buses

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Trip Overview

The average bus between Milan and Sistine Chapel takes 9h 4m and the fastest bus takes 8h 59m. There is at least one bus per day from Milan to Sistine Chapel. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

9h 4m
Duration
597 km
Distance
€44
Average price
Once daily
Frequency

Milan to Sistine Chapel bus times

Buses run once daily between Milan and Sistine Chapel. The service departs Milan at 9:00 PM at night, which arrives into Sistine Chapel at 06:05:14. All services require a transfer at Rome Tiburtina Largo Mazzoni and take an average of 9h 4m. The schedules shown below are for the next available departures.

Departing Wednesday, November 11, 2026

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    Arrives next day

    Itabus S.p.A.ATAC S.p.A. Azienda per la mobilità9h 5m • 1 change

Departing Thursday, November 12, 2026

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    Arrives next day

    Itabus S.p.A.ATAC S.p.A. Azienda per la mobilità9h 5m • 1 change

Departing Friday, November 13, 2026

  •  → 

    Arrives next day

    Itabus S.p.A.ATAC S.p.A. Azienda per la mobilità9h • 1 change

Departing Saturday, November 14, 2026

  •  → 

    Arrives next day

    Itabus S.p.A.ATAC S.p.A. Azienda per la mobilità8h 59m • 1 change

Departing Sunday, November 15, 2026

  •  → 

    Arrives next day

    Itabus S.p.A.ATAC S.p.A. Azienda per la mobilità9h 6m • 1 change

Departing Monday, November 16, 2026

  •  → 

    Arrives next day

    Itabus S.p.A.ATAC S.p.A. Azienda per la mobilità9h 6m • 1 change

Frequently asked questions

Want to know about travelling from Milan to Sistine Chapel? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from Milan to Sistine Chapel.ExpandLaunch map view
  • Distance: 597 km
  • Duration: 9h 4m

What companies run services between Milan, Italy and Sistine Chapel, Vatican City?

Itabus S.p.A. operates a bus from Milano, San Donato M3 to Rome Tiburtina Largo Mazzoni once daily. Tickets cost €30–55 and the journey takes 7h 30m.

Operators