The average bus between Naples and Sistine Chapel takes 3h 43m and the fastest bus takes 3h 11m. There is a bus service every few hours from Naples to Sistine Chapel. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run hourly between Naples and Sistine Chapel. The earliest departure is at 2:40 AM at night, and the last departure from Naples is at 8:20 PM which arrives into Sistine Chapel at 11:50 PM. All services require a transfer at Roma, Autostazione Tiburtina and take an average of 3h 43m. The schedules shown below are for the next available departures.

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3h 20m • 1 changeWant to know about travelling from Naples to Sistine Chapel? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Naples to Sistine Chapel. However, there are services departing from Napoli P.zza Garibaldi station and arriving at Cavalleggeri/S. Pietro station via Roma, Autostazione Tiburtina station. The journey, including transfers, takes approximately 3h 43m.
Naples to Sistine Chapel bus services, operated by FlixBus, depart from Napoli P.zza Garibaldi station.
Naples to Sistine Chapel bus services, operated by ATAC S.p.A. Azienda per la mobilità, arrive at Cavalleggeri/S. Pietro station.
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The distance between Naples and Sistine Chapel is 191.2 km. The road distance is 222 km.
You can take a bus from Napoli P.zza Garibaldi to Sistine Chapel via Roma, Autostazione Tiburtina and Cavalleggeri/S. Pietro in around 3h 49m.