The average bus between Manchester and Siena takes 37h 1m and the fastest bus takes 35h 55m. The bus service runs several times per day from Manchester to Siena. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run twice daily between Manchester and Siena. The earliest departure is at 5:00 AM in the morning, and the last departure from Manchester is at 11:59 PM which arrives into Siena at 2:20 PM. All services require a transfer at London Victoria and take an average of 37h 1m. The schedules shown below are for the next available departures.
Arrives next day




37h 55m • 4 changes
Arrives +2 days




38h 21m • 4 changes
Arrives next day




37h 55m • 4 changes
Arrives +2 days




38h 21m • 4 changes
Arrives next day




37h 55m • 4 changes
Arrives +2 days




38h 21m • 4 changes
Want to know about travelling from Manchester to Siena? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Manchester to Siena. However, there are services departing from Manchester station and arriving at Siena station via London Victoria. The journey, including transfers, takes approximately 37h 1m.
Manchester to Siena bus services, operated by FlixBus, depart from Manchester, Shudehill Interchange station.
Manchester to Siena bus services, operated by FlixBus, arrive at Siena station.
Book your Manchester to Siena bus tickets online with FlixBus and BlaBlaCar Bus.
The distance between Manchester and Siena is 1,505 km. The road distance is 2,043 km.
You can take a bus from Manchester, Shudehill Interchange to Siena via London Victoria, Dover, Paris, Quai de Bercy (Bercy Seine), Paris - Bercy-Seine Bus Station, and Florence Villa Constanza Bus Station in around 33h 16m.