The average bus between Mainz and Strasbourg takes 4h 25m and the fastest bus takes 4h 7m. The bus service runs several times per day from Mainz to Strasbourg. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run every 4 hours between Mainz and Strasbourg. The earliest departure is at 3:54 AM at night, and the last departure from Mainz is at 7:18 PM which arrives into Strasbourg at 9:40 PM. All services require a transfer at Frankfurt and take an average of 4h 25m. The schedules shown below are for the next available departures.

4h 41m • 1 change

2h 42m • 1 change

4h 32m • 1 change

4h 17m • 1 change

4h 41m • 1 change

2h 27m • 1 change

4h 32m • 1 change

4h 17m • 1 change

4h 41m • 1 change

2h 27m • 1 change

4h 32m • 1 change

4h 17m • 1 change

4h 41m • 1 change

4h 32m • 1 change

4h 17m • 1 change

4h 7m • 1 change

4h 41m • 1 change

4h 32m • 1 change

4h 17m • 1 change

2h 27m • 1 change

4h 41m • 1 change

2h 27m • 1 change

4h 32m • 1 change

4h 17m • 1 change
Want to know about travelling from Mainz to Strasbourg? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Mainz to Strasbourg. However, there are services departing from Mainz station and arriving at Strasbourg station via Strasbourg - L'Étoile Park Bus Station station. The journey, including transfers, takes approximately 4h 25m.
Mainz to Strasbourg bus services, operated by DB Bus, depart from Frankfurt - Airport Bus Station.
Mainz to Strasbourg bus services, operated by DB Bus, arrive at Strasbourg - L'Étoile Park Bus Station.
Book your Mainz to Strasbourg bus tickets online with DB Bus, FlixBus and BlaBlaCar Bus.
The distance between Mainz and Strasbourg is 160.4 km. The road distance is 238 km.
BlaBlaCar Bus operates a bus from Frankfurt - Airport Bus Station to Strasbourg - L'Étoile Park Bus Station 5 times a day. Tickets cost €18–35 and the journey takes 3h 35m. FlixBus also services this route every 4 hours.