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Madison to St. Louis (Region) buses

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Trip Overview

The average bus between Madison and St. Louis (Region) takes 10h 55m and the fastest bus takes 10h 10m. The bus service runs several times per day from Madison to St. Louis (Region). The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

10h 55m
Duration
475 mi
Distance
$113
Average price
Twice daily
Frequency

Madison to St. Louis (Region) bus times

Buses run twice daily between Madison and St. Louis (Region). The earliest departure is at 5:30 AM in the morning, and the last departure from Madison is at 6:30 PM which arrives into St. Louis (Region) at 6:20 AM. All services require a transfer at W Jackson Blvd, after S Clinton St and take an average of 10h 55m. The schedules shown below are for the next available departures.

Departing Wednesday, November 11, 2026

  •  → 

    Arrives next day

    Rockland CoachesFlixbus USA11h 50m • 1 change

Departing Thursday, November 12, 2026

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    Rockland CoachesFlixbus USA10h 10m • 1 change
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    Rockland CoachesFlixbus USA10h 45m • 1 change
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    Arrives next day

    Rockland CoachesFlixbus USA11h 50m • 1 change

Departing Friday, November 13, 2026

  •  → 

    Rockland CoachesFlixbus USA10h 10m • 1 change
  •  → 

    Rockland CoachesFlixbus USA10h 45m • 1 change
  •  → 

    Arrives next day

    Rockland CoachesFlixbus USA11h 50m • 1 change

Departing Saturday, November 14, 2026

  •  → 

    Rockland CoachesFlixbus USA10h 10m • 1 change
  •  → 

    Rockland CoachesFlixbus USA10h 45m • 1 change
  •  → 

    Arrives next day

    Rockland CoachesFlixbus USA11h 50m • 1 change

Departing Sunday, November 15, 2026

  •  → 

    Rockland CoachesFlixbus USA10h 10m • 1 change
  •  → 

    Rockland CoachesFlixbus USA10h 45m • 1 change
  •  → 

    Arrives next day

    Rockland CoachesFlixbus USA11h 50m • 1 change

Departing Monday, November 16, 2026

  •  → 

    Rockland CoachesFlixbus USA10h 10m • 1 change
  •  → 

    Rockland CoachesFlixbus USA10h 45m • 1 change

Frequently asked questions

Want to know about travelling from Madison to St. Louis (Region)? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from Madison to St. Louis (Region).ExpandLaunch map view
  • Distance: 474.8 mi
  • Duration: 10h 55m

What companies run services between Madison, WI, USA and St. Louis (Region), MO, USA?

You can take a bus from 250 N. Lake St - Madison UW Campus to St Louis Bus Station via W Jackson Blvd, after S Clinton St and Chicago Bus Station in around 11h 2m.

Operators