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How to get fromMadison to St. Louis (Region)by bus, train, bus (Flixbus), car, or plane

Find Transport to St. Louis (Region)

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There are 7 ways to get from Madison to St. Louis (Region) by bus, train, bus (Flixbus), car, or plane

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus, train

    best
    1. Take the bus from 250 N. Lake St - Madison UW Campus to W Jackson Blvd, after S Clinton Stbus bus Van Galder
    2. Take the train from Chicago Union Station to St. Louistrain train Lincoln Service / ...
    9h 46m
    $116–246

  2. Drive 358.6 mi

    cheapest
    1. Drive from Madison to St. Louis (Region)car car 358.6 mi
    5h 54m
    $66–95

  3. Bus

    1. Take the bus from 250 N. Lake St - Madison UW Campus to W Jackson Blvd, after S Clinton Stbus bus Van Galder
    2. Take the bus from Chicago Bus Station to St Louis Bus Stationbus bus FlixBus 2510 / ...
    11h 2m
    $76–141

  4. Fly from Dane County Regional Airport-Truax Field

    1. Fly from Dane County Regional Airport-Truax Field (MSN) to Lambert–St. Louis International Airport (STL)plane plane MSN - STL
    5h 52m
    $105–655

  5. Bus, train via Milwaukee

    1. Take the bus from UW Madison Campus - N Lake St to Milwaukee Intermodalbus bus
    2. Take the train from Milwaukee to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to St. Louistrain train
    9h 50m
    $130–274

  6. Bus to General Mitchell International Airport, fly

    1. Take the bus from UW Madison Campus - N Lake St to Mitchell Airportbus bus
    2. Fly from General Mitchell International Airport (MKE) to Lambert–St. Louis International Airport (STL)plane plane MKE - STL
    4h 58m
    $497–876

  7. Bus to Chicago O'Hare International Airport, fly

    1. Take the bus from 250 N. Lake St - Madison UW Campus to O'Hare International Airport - Terminal 1 Departuresbus bus
    2. Fly from Chicago O'Hare International Airport (ORD) to Lambert–St. Louis International Airport (STL)plane plane ORD - STL
    5h 57m
    $297–753

Madison to St. Louis (Region) by bus and train

Calendar38Weekly Services
Duration9h 46mAverage Duration
Ticket$116Cheapest Price
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Questions & Answers

Map of how to get from Madison to St. Louis (Region).ExpandLaunch map view
  • Distance: 437.7 mi
  • Duration: 9h 46m

What companies run services between Madison, WI, USA and St. Louis (Region), MO, USA?

You can take a bus from 250 N. Lake St - Madison UW Campus to St Louis Bus Station via W Jackson Blvd, after S Clinton St and Chicago Bus Station in around 11h 2m. Alternatively, United Airlines, Delta, and American Airlines fly from Dane County Regional Airport-Truax Field (MSN) to Lambert–St. Louis International Airport (STL) hourly.

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