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Memphis to St. Louis (Region) buses

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Trip Overview

The average bus between Memphis and St. Louis (Region) takes 6h 19m and the fastest bus takes 5h 56m. The bus service runs several times per day from Memphis to St. Louis (Region). The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

6h 19m
Duration
305 mi
Distance
$66
Average price
Twice daily
Frequency

Memphis to St. Louis (Region) bus times

Buses run twice daily between Memphis and St. Louis (Region). The earliest departure is at 8:17 AM in the morning, and the last departure from Memphis is at 4:17 PM which arrives into St. Louis (Region) at 11:00 PM. All services require a transfer, and take on average 6h 19m. The schedules shown below are for the next available departures.

Departing Tuesday, November 10, 2026

  •  → 

    MATA TransitGreyhound USA6h 42m • 1 change

Departing Wednesday, November 11, 2026

  •  → 

    MATA TransitFlixbus USA5h 56m • 1 change
  •  → 

    MATA TransitGreyhound USA6h 42m • 1 change

Departing Thursday, November 12, 2026

  •  → 

    MATA TransitFlixbus USA5h 56m • 1 change
  •  → 

    MATA TransitGreyhound USA6h 42m • 1 change

Departing Friday, November 13, 2026

  •  → 

    MATA TransitFlixbus USA5h 56m • 1 change
  •  → 

    MATA TransitGreyhound USA6h 42m • 1 change

Departing Saturday, November 14, 2026

  •  → 

    MATA TransitFlixbus USA5h 57m • 1 change
  •  → 

    MATA TransitGreyhound USA6h 42m • 1 change

Departing Monday, November 16, 2026

  •  → 

    MATA TransitFlixbus USA5h 56m • 1 change
  •  → 

    MATA TransitGreyhound USA6h 42m • 1 change

Frequently asked questions

Want to know about travelling from Memphis to St. Louis (Region)? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from Memphis to St. Louis (Region).ExpandLaunch map view
  • Distance: 305.2 mi
  • Duration: 6h 19m

What companies run services between Memphis, TN, USA and St. Louis (Region), MO, USA?

Greyhound USA operates a bus from Memphis Bus Station to St Louis Bus Station once daily. Tickets cost $50–80 and the journey takes 5h 15m. Flixbus USA also services this route 5 times a week.

Operators