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Madison to Des Moines buses

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Trip Overview

The bus between Madison and Des Moines takes 10h 20m. There is at least one bus per day from Madison to Des Moines. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

10h 20m
Duration
507 mi
Distance
$130
Average price
Once daily
Frequency

Madison to Des Moines bus times

Buses run once daily between Madison and Des Moines. The service departs Madison at 6:45 PM in the evening, which arrives into Des Moines at 05:05:00. All services require a transfer, and take on average 10h 20m. The schedules shown below are for the next available departures.

Departing Wednesday, November 11, 2026

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    Arrives next day

    Greyhound USAGreyhound USA10h 20m • 1 change

Departing Thursday, November 12, 2026

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    Arrives next day

    Greyhound USAGreyhound USA10h 20m • 1 change

Departing Friday, November 13, 2026

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    Arrives next day

    Greyhound USAGreyhound USA10h 20m • 1 change

Departing Saturday, November 14, 2026

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    Arrives next day

    Greyhound USAGreyhound USA10h 20m • 1 change

Departing Sunday, November 15, 2026

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    Arrives next day

    Greyhound USAGreyhound USA10h 20m • 1 change

Departing Monday, November 16, 2026

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    Arrives next day

    Greyhound USAGreyhound USA10h 20m • 1 change

Frequently asked questions

Want to know about travelling from Madison to Des Moines? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from Madison to Des Moines.ExpandLaunch map view
  • Distance: 507.4 mi
  • Duration: 10h 20m

What companies run services between Madison, WI, USA and Des Moines, IA, USA?

You can take a bus from Madison to Des Moines via Saint Paul Union Depot in around 10h 20m.

Operators