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Portland to Des Moines buses

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Trip Overview

The bus between Portland and Des Moines takes 45h 40m. The bus runs, on average, 5 times per week from Portland to Des Moines. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

45h 40m
Duration
2,050 mi
Distance
$430
Average price
5 times a week
Frequency

Portland to Des Moines bus times

Buses run 5 times a week between Portland and Des Moines. The service departs Portland at 9:15 AM in the morning, which arrives into Des Moines at 08:55:00. All services require a transfer at Pasco Bus Stop and take an average of 45h 40m. The schedules shown below are for the next available departures.

Departing Saturday, November 14, 2026

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    Arrives +2 days

    Flixbus USAGreyhound USAGreyhound USA45h 40m • 2 changes

Departing Sunday, November 15, 2026

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    Arrives +2 days

    Flixbus USAGreyhound USAGreyhound USA45h 40m • 2 changes

Departing Monday, November 16, 2026

  •  → 

    Arrives +2 days

    Flixbus USAGreyhound USAGreyhound USA45h 40m • 2 changes

Departing Tuesday, November 17, 2026

  •  → 

    Arrives +2 days

    Flixbus USAGreyhound USAGreyhound USA45h 40m • 2 changes

Departing Wednesday, November 18, 2026

  •  → 

    Arrives +2 days

    Flixbus USAGreyhound USAGreyhound USA45h 40m • 2 changes

Frequently asked questions

Want to know about travelling from Portland to Des Moines? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from Portland to Des Moines.ExpandLaunch map view
  • Distance: 2,050 mi
  • Duration: 45h 40m

What companies run services between Portland, OR, USA and Des Moines, IA, USA?

You can take a bus from Portland Curbside Bus Stop to Des Moines via Pasco Bus Stop and Denver Union Station in around 41h 40m.

Operators