The average bus between Lyon and Perugia takes 14h 12m and the fastest bus takes 12h 40m. The bus service runs several times per day from Lyon to Perugia. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run 3 times a day between Lyon and Perugia. The earliest departure is at 1:15 AM at night, and the last departure from Lyon is at 11:59 PM which arrives into Perugia at 1:45 PM. All services require a transfer, and take on average 14h 12m. The schedules shown below are for the next available departures.

16h 50m • 1 change

13h 40m • 1 change

12h 40m • 1 change
Arrives next day

14h 50m • 1 change

16h 50m • 1 change

13h 40m • 1 change

12h 40m • 1 change
Arrives next day

14h 50m • 1 change

16h 50m • 1 change

13h 40m • 1 change

12h 40m • 1 change
Arrives next day

14h 50m • 1 change
Want to know about travelling from Lyon to Perugia? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Lyon to Perugia. However, there are services departing from Lyon station and arriving at Perugia station via Florence Villa Constanza Bus Station station. The journey, including transfers, takes approximately 14h 12m.
Lyon to Perugia bus services, operated by FlixBus, depart from Lyon station.
Lyon to Perugia bus services, operated by FlixBus, arrive at Perugia station.
Book your Lyon to Perugia bus tickets online with FlixBus and BlaBlaCar Bus.
The distance between Lyon and Perugia is 666.4 km. The road distance is 907 km.
You can take a bus from Lyon to Perugia via Florence Villa Constanza Bus Station in around 13h 45m.