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Lowell to St. Louis buses

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Trip Overview

The bus between Lowell and St. Louis takes 2d 4h. The bus runs, on average, 4 times per week from Lowell to St. Louis. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

2d 4h
Duration
1,276 mi
Distance
$271
Average price
4 times a week
Frequency

Lowell to St. Louis bus times

Buses run 4 times a week between Lowell and St. Louis. The service departs Lowell at 7:50 PM in the evening, which arrives into St. Louis at 22:50:00. All services require a transfer at Boston and take an average of 2d 4h. The schedules shown below are for the next available departures.

Departing Thursday, November 12, 2026

  •  → 

    Arrives +2 days

    Greyhound USAFlixbus USAGreyhound USA2d 4h • 2 changes

Departing Friday, November 13, 2026

  •  → 

    Arrives +2 days

    Greyhound USAFlixbus USAGreyhound USA2d 4h • 2 changes

Departing Saturday, November 14, 2026

  •  → 

    Arrives +2 days

    Greyhound USAFlixbus USAGreyhound USA2d 4h • 2 changes

Departing Sunday, November 15, 2026

  •  → 

    Arrives +2 days

    Greyhound USAFlixbus USAGreyhound USA2d 4h • 2 changes

Frequently asked questions

Want to know about travelling from Lowell to St. Louis? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from Lowell to St. Louis.ExpandLaunch map view
  • Distance: 1,276.5 mi
  • Duration: 2d 4h

What companies run services between Lowell, MA, USA and St. Louis, MO, USA?

You can take a bus from Robert B Kennedy Bus Transfer Center to St Louis Bus Station via Boston and Newark Penn Station in around 29h 50m.

Operators