Rome2Rio

How to get fromLowell to St. Louisby plane, train (Amtrak), bus (Greyhound), car, train, or bus

Find Transport to St. Louis

See all options

There are 6 ways to get from Lowell to St. Louis by plane, train (Amtrak), bus (Greyhound), car, train, or bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Boston Logan Airport

    best
    1. Fly from Boston Logan Airport (BOS) to Lambert–St. Louis International Airport (STL)plane plane BOS - STL
    5h 47m
    $374–870

  2. Train, train to Theodore Francis Green State Airport, fly

    cheapest
    1. Take the train from Lowell to North Stationtrain train
    2. Take the train from Ruggles to TF Green Airporttrain train
    3. Fly from Theodore Francis Green State Airport (PVD) to Lambert–St. Louis International Airport (STL)plane plane PVD - STL
    9h 36m
    $150–681

  3. Train

    1. Take the train from Lowell to North Stationtrain train
    2. Take the train from Boston to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to St. Louistrain train
    29h 57m
    $403–903

  4. Bus

    1. Take the bus from Robert B Kennedy Bus Transfer Center to Bostonbus bus
    2. Take the bus from Boston to New Yorkbus bus
    3. Take the bus from Port Authority Bus Terminal to St Louis Bus Stationbus bus
    30h 17m
    $199–418

  5. Drive 1,152.5 mi

    1. Drive from Lowell to St. Louiscar car 1,152.5 mi
    20h 29m
    $211–304

  6. Train, bus to Manchester Airport, fly

    1. Take the train from Lowell to North Stationtrain train
    2. Take the bus from Boston to Boston Manchester Airportbus bus
    3. Fly from Manchester Airport (MHT) to Lambert–St. Louis International Airport (STL)plane plane MHT - STL
    9h 14m
    $188–881

Lowell to St. Louis by train and subway

Calendar7Weekly Services
Duration29h 57mAverage Duration
Ticket$403Cheapest Price
See schedules

Comparing Your Travel Options

Map of how to get from Lowell to St. Louis.ExpandLaunch map view
  • Distance: 1,085.5 mi
  • Duration: 5h 47m

What companies run services between Lowell, MA, USA and St. Louis, MO, USA?

American Airlines, Southwest Airlines, and United Airlines fly from Boston Logan Airport (BOS) to Lambert–St. Louis International Airport (STL) every 4 hours. Alternatively, you can take a train from Lowell to St. Louis via North Station, North Station, Back Bay, Boston, and Chicago Union Station in around 29h 57m.

Airlines
Train operators
Bus operators

Want to know more about travelling around United States

Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

Related travel guides

Need to know: Greyhound

Read the travel guideNeed to know: Greyhound

Booking & Getting There