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How to get fromLouisville to Key Westby car, plane, bus (Amtrak, Greyhound, Flixbus), bus or shuttle

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There are 7 ways to get from Louisville to Key West by car, plane, bus (Amtrak, Greyhound, Flixbus), bus, or shuttle

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Drive to Blue Grass Airport, fly

    best
    1. Drive from Louisville to Lexington-Airport-LEXcar car
    2. Fly from Blue Grass Airport (LEX) to Key West International Airport (EYW)plane plane LEX - EYW
    5h 37m
    $124–582
  2. Bus

    1. Take the bus from Louisville, KY to Nashvillebus bus
    2. Take the bus from Nashville Bus Station to Atlanta Bus Stationbus bus
    3. Take the bus from Atlanta Bus Station to Miami Airport Stationbus bus
    4. Take the bus from Miami Airport Station to Big Pine Keybus bus
    5. Take the bus from Big Pine Key - CVS / MM30 to N Roosevelt & 3rd Streetbus bus Lks
    29h 51m
    $141–315
  3. Drive 1,175.1 mi

    1. Drive from Louisville to Key Westcar car 1,175.1 mi
    22h 4m
    $215–310
  4. Fly from Louisville International Airport

    1. Fly from Louisville International Airport (SDF) to Key West International Airport (EYW)plane plane SDF - EYW
    6h 22m
    $143–716
  5. Bus to Evansville, fly

    1. Take the bus from Louisville, KY to Evansville, INbus bus
    2. Fly from Evansville (EVV) to Key West International Airport (EYW)plane plane EVV - EYW
    8h 26m
    $200–789
  6. Bus to Covington, fly

    1. Take the bus from Louisville, KY Bus Station to Cincinnati - Downtownbus bus
    2. Fly from Covington (CVG) to Key West International Airport (EYW)plane plane CVG - EYW
    6h 37m
    $203–1,008
  7. Bus, shuttle

    1. Take the bus from Louisville, KY to Nashvillebus bus
    2. Take the bus from Nashville Bus Station to Tallahasseebus bus
    3. Take the bus from Tallahassee - FSU - Old St Augustine at Intramural Field to Miami Airportbus bus
    4. Take a shuttle bus from Miami, FL - International Airport to Key West, FLshuttle bus
    30h 54m
    $311–542

Louisville to Key West by bus and foot

Calendar14Weekly Services
Duration29h 51mAverage Duration
Ticket$141Cheapest Price
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Questions & Answers

What companies run services between Louisville, KY, USA and Key West, FL, USA?

You can take a bus from Louisville, KY to N Roosevelt & 3rd Street via Nashville Bus Station, Atlanta Bus Station, Miami Airport Station, Big Pine Key, and Big Pine Key - CVS / MM30 in around 29h 51m. Alternatively, Delta, American Airlines, and two other airlines fly from Louisville International Airport (SDF) to Key West International Airport (EYW) 4 times a day.

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