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Anna Maria Island to Key Largo buses

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Trip Overview

The average bus between Anna Maria Island and Key Largo takes 16h 48m and the fastest bus takes 16h 30m. The bus runs, on average, 5 times per week from Anna Maria Island to Key Largo. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

16h 48m
Duration
330 mi
Distance
$60
Average price
5 times a week
Frequency

Anna Maria Island to Key Largo bus times

Buses run 5 times a week between Anna Maria Island and Key Largo. The earliest departure is at 12:25 PM in the afternoon, and the last departure from Anna Maria Island is at 1:55 PM which arrives into Key Largo at 6:25 AM. All services require a transfer at Downtown Station and take an average of 16h 48m. The schedules shown below are for the next available departures.

Departing Monday, November 16, 2026

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    Arrives next day

    Manatee County Area TransitSarasota County Area TransitSarasota County Area TransitFlixbus USAGreyhound USA16h 30m • 4 changes

Departing Tuesday, November 17, 2026

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    Arrives next day

    Manatee County Area TransitSarasota County Area TransitSarasota County Area TransitFlixbus USAGreyhound USA16h 30m • 4 changes

Departing Wednesday, November 18, 2026

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    Arrives next day

    Manatee County Area TransitSarasota County Area TransitSarasota County Area TransitFlixbus USAGreyhound USA18h • 4 changes

Departing Thursday, November 19, 2026

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    Arrives next day

    Manatee County Area TransitSarasota County Area TransitSarasota County Area TransitFlixbus USAGreyhound USA16h 30m • 4 changes

Departing Friday, November 20, 2026

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    Arrives next day

    Manatee County Area TransitSarasota County Area TransitSarasota County Area TransitFlixbus USAGreyhound USA16h 30m • 4 changes

Frequently asked questions

Want to know about travelling from Anna Maria Island to Key Largo? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from Anna Maria Island to Key Largo.ExpandLaunch map view
  • Distance: 330.5 mi
  • Duration: 16h 48m

What companies run services between Anna Maria Island, FL, USA and Key Largo, FL, USA?

You can take a bus from Gulf Dr/42Nd St to Key Largo Bus Stop via Downtown Station, 13Th St W @ 6Th Ave W Ns, Downtown Transfer Station, Cattlemen Transit Station, Sarasota Cattlemen Transfer Center, and Miami Airport Station in around 10h 18m.

Operators